{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:48:12Z","timestamp":1785937692516,"version":"3.56.0"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","award":["261366"],"award-info":[{"award-number":["261366"]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) and psoriasis (PSO) are chronic inflammatory skin diseases that impose substantial physical and psychological burdens. Although fungal\u2010bacterial balance is important for skin immune homeostasis, the role of the skin mycobiome and its interaction with bacterial communities and host immunity in these diseases remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize alterations in the skin mycobiome and its interactions with bacterial communities and host immune responses in AD and PSO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients with chronic AD, plaque\u2010type PSO and healthy volunteers were included in this study. Skin microbiota samples and biopsies were collected from lesional and non\u2010lesional skin areas, including the posterior thigh for AD and the lower back for PSO. Whole\u2010metagenome shotgun sequencing was used to profile microbial communities. SparCC was used to construct fungal\u2010bacterial co\u2010occurrence networks, and integration of host transcriptomic and microbial features was performed using O2PLS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both AD and PSO showed disease\u2010associated restructuring of\n                      <jats:italic>Malassezia<\/jats:italic>\n                      species and reduced fungal\u2013bacterial ecological connectivity in lesional skin. In AD,\n                      <jats:italic>Malassezia arunalokei<\/jats:italic>\n                      was inversely associated with\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      and linked to antimicrobial peptide\u2010centred host gene modules enriched for IL\u201017 signalling. Its abundance decreased with increasing disease severity and inversely correlated with inflammatory immune cell signatures. In PSO, altered\n                      <jats:italic>Malassezia<\/jats:italic>\n                      composition was associated with IL\u201017\u2010driven transcriptional programmes and lipid metabolic pathways, suggesting interactions between fungal imbalance and inflammatory\u2010metabolic processes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings expand current models of skin dysbiosis beyond bacteria and suggest that disrupted fungal\u2013bacterial interactions are linked to immune activation in AD and PSO and, in AD, to disease severity. Although further validation is required, skin microbiome features may provide clinically relevant information for disease monitoring, patient stratification and future microbiome\u2010informed therapeutic strategies. Our study lays the groundwork for microbiome modulation as a potential therapeutic strategy for AD and PSO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70654","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:19:19Z","timestamp":1785935959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010omics analyses reveal host\u2013microbe interactions in atopic dermatitis and psoriasis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3839-6859","authenticated-orcid":false,"given":"Ying","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Olah","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical Faculty and University Hospital Duesseldorf Heinrich\u2010Heine University Duesseldorf  Duesseldorf Germany"},{"name":"Department of Dermatology, Venereology and Oncodermatology, Medical Faculty University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5471-5894","authenticated-orcid":false,"given":"Alexander","family":"Salava","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University of Helsinki and Helsinki University Hospital, Inflammation Center  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Barker","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Lauerma","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University of Helsinki and Helsinki University Hospital, Inflammation Center  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna","family":"Fyhrquist","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Health Sciences Karlstad University  Karlstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Homey","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical Faculty and University Hospital Duesseldorf Heinrich\u2010Heine University Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Alenius","sequence":"additional","affiliation":[{"name":"Institute of 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