{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:13:39Z","timestamp":1788164019886,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005940","name":"Dansk Kr\u00e6ftforsknings Fond","doi-asserted-by":"publisher","award":["PLSNR\u2010ACTIVE.FID2444075"],"award-info":[{"award-number":["PLSNR\u2010ACTIVE.FID2444075"]}],"id":[{"id":"10.13039\/501100005940","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R368 A21609"],"award-info":[{"award-number":["R368 A21609"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adjuvant anti\u2010PD\u20101 therapy improves recurrence\u2010free survival in resected stage III melanoma, but its impact on survival remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association of adjuvant anti\u2010PD\u20101 therapy with overall survival (OS) and melanoma\u2010specific mortality (MSM) in patients with stage III melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Five\u2010year OS and MSM were compared between stage III melanoma patients diagnosed before (pre\u2010cohort: June 2016\u2013May 2018,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009450) and after (post\u2010cohort: January 2019\u2013December 2020,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009552) implementation of adjuvant anti\u2010PD\u20101 in Denmark. Post\u2010cohort patients receiving adjuvant anti\u2010PD\u20101 were propensity score\u2010matched to pre\u2010cohort patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow\u2010up exceeded 5\u2009years in both cohorts. At the population level, no difference in 5\u2010year OS or MSM was demonstrated between the total cohorts. In the post\u2010cohort, 297 patients (53.8%) received adjuvant anti\u2010PD\u20101. After matching (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009279 per group), adjuvant anti\u2010PD\u20101 was associated with higher 5\u2010year OS (80.3% vs. 71.7%; HR 0.67, 95% CI 0.47\u20130.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). 5\u2010year MSM estimates were inconclusive (16.6% vs. 20.8%, HR 0.77, 95% CI 0.52\u20131.14;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.24). Among matched patients with occult nodal disease, results were also inconclusive (OS HR 0.70, 95% CI 0.46\u20131.06). Sensitivity power analyses indicated that only large effects were detectable given the available events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We were unable to demonstrate an improved survival at the population level after adjuvant anti\u2010PD\u20101 introduction, but matched analysis showed higher OS in treated patients. However, uncertainty in disease\u2010specific outcomes and limited power preclude firm conclusions. Mature trial data are essential for defining the role of adjuvant therapy alongside emerging neoadjuvant strategies. Until then, carefully individualized adjuvant treatment decisions are of particular importance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70692","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:15:27Z","timestamp":1788160527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Five\u2010year survival impact of adjuvant anti\u2010\n                    <scp>PD<\/scp>\n                    \u20101 therapy in a nationwide cohort of stage\n                    <scp>III<\/scp>\n                    melanoma"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-8849","authenticated-orcid":false,"given":"Marie B.","family":"Weitemeyer","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Copenhagen University Hospital \u2013 Herlev and Gentofte  Herlev 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