{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:03:41Z","timestamp":1789322621009,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of atopic dermatitis (AD) on pregnancy outcomes has been largely uncertain, and clarifying this association is essential for improving maternal counselling, risk stratification and clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the association between AD in pregnant women and adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE, Embase and CENTRAL were searched from inception through 7th September 2025. We included cohort studies that assessed the association between AD and pregnancy outcomes. Maternal outcomes included mode of delivery, obstetric complications and maternal mortality. Neonatal outcomes included preterm birth, perinatal mortality, impaired foetal growth, congenital anomalies, neonatal infections and other adverse neonatal outcomes. We used the Newcastle\u2013Ottawa Scale (NOS) to assess the risk of bias of included studies. A random\u2010effects model meta\u2010analysis was undertaken.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included eight cohort studies involving 278,671 women with AD and over 2,738,216 controls. The meta\u2010analysis found associations of maternal AD with premature rupture of membranes [pooled odds ratio (OR) 1.16, 95% confidence interval (CI) 1.09\u20131.24] and low birth weight (&lt;2500\u2009g, pooled OR 1.11, 95% CI 1.02\u20131.20). Maternal AD was also associated with increased risk of gestational hypertension (pooled OR 1.15, 95% CI 1.02\u20131.29) and pre\u2010eclampsia\/eclampsia (pooled OR 1.11; 95% CI 1.03\u20131.19). One study indicated increased neonatal septicaemia caused by\n                      <jats:italic>Staphylococcal<\/jats:italic>\n                      species (OR 2.45, 95% CI 1.33\u20134.49).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Maternal AD is associated with a modestly increased risk of premature rupture of membranes, gestational hypertension, pre\u2010eclampsia\/eclampsia and notably neonatal\n                      <jats:italic>Staphylococcal<\/jats:italic>\n                      septicaemia. Obstetricians and dermatologists should be aware of these risks, monitor pregnancy complications closely and provide appropriate management when necessary.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70738","type":"journal-article","created":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T17:36:27Z","timestamp":1789320987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adverse pregnancy outcomes in women with atopic dermatitis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9105-8771","authenticated-orcid":false,"given":"Wan\u2010Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Education Chang Gung Memorial Hospital, Linkou Main Branch  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9921-9632","authenticated-orcid":false,"given":"Elisa","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Education Chang Gung Memorial Hospital, Linkou Main Branch  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1577-5357","authenticated-orcid":false,"given":"Cheng\u2010Chen","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Medical Education Chang Gung Memorial Hospital, Linkou Main Branch  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-0283","authenticated-orcid":false,"given":"Ching\u2010Chi","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chang Gung Memorial Hospital, Linkou Main Branch  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad339"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.01.010"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.2.180"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v105.42544"},{"key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/ddg.15555","article-title":"Atopic dermatitis and the outcomes of pregnancy and offspring: a nationwide population\u2010based study in Taiwan","volume":"23","author":"Weng PC","year":"2024","journal-title":"JDDG"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-024-03950-2"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604.ch1"},{"issue":"4","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/1027-8117.362992","article-title":"Ten essential steps for performing a systematic review: a quick tutorial","volume":"40","author":"Kuo LT","year":"2022","journal-title":"Dermatol Sin"},{"key":"e_1_2_13_12_1","unstructured":"WellsG SheaB O'ConnellD Petersonj WelchV LososM et\u00a0al.The Newcastle\u2013Ottawa Scale (NOS) for assessing the quality of non\u2010randomized studies in meta\u2010analysis.https:\/\/ohri.ca\/en\/who\u2010we\u2010are\/core\u2010facilities\u2010and\u2010platforms\/ottawa\u2010methods\u2010centre\/newcastle\u2010ottawa\u2010scale."},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.19.1690"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2017.05.049"},{"issue":"1","key":"e_1_2_13_15_1","first-page":"26","article-title":"Pregnancy outcome in women with threatened miscarriage: a year study","volume":"24","author":"Ahmed SR","year":"2012","journal-title":"Mater Soc"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.055"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13595"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.126"},{"key":"e_1_2_13_19_1","volume-title":"Williams O,bstetrics","author":"Cunningham F","year":"2009"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15256"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14635"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000513749"},{"issue":"1","key":"e_1_2_13_23_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000096910","article-title":"Pregnancy and pregnancy outcome among women with inflammatory skin diseases","volume":"214","author":"Seeger JD","year":"2007","journal-title":"Dermatology (Basel)"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12154"},{"issue":"4","key":"e_1_2_13_25_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2022.100123","article-title":"Atopic dermatitis is associated with preeclampsia and endometriosis","volume":"2","author":"Barbieri JS","year":"2022","journal-title":"JID Innovations"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2006.04.001"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.016"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02025"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.015"},{"issue":"3","key":"e_1_2_13_30_1","first-page":"243","article-title":"TH17\u2010 and IL\u201017\u2010 mediated autoantibodies and placental oxidative stress play a role in the pathophysiology of pre\u2010eclampsia","volume":"66","author":"Cornelius DC","year":"2014","journal-title":"Minerva Ginecol"},{"issue":"4","key":"e_1_2_13_31_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/01443615.2016.1250734","article-title":"Expression of matrix metalloproteinase\u20109 and its substrate level in patients with premature rupture of membranes","volume":"37","author":"Zuo G","year":"2017","journal-title":"J Obstet Gynaecol"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09467.x"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20639"},{"key":"e_1_2_13_34_1","first-page":"CD007346","article-title":"Safety of topical corticosteroids in pregnancy","volume":"10","author":"Chi CC","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.5768"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200104270-00006"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.10.072"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19794"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20670"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.063"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.70738","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T17:36:29Z","timestamp":1789320989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.70738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,13]]},"references-count":39,"alternative-id":["10.1111\/jdv.70738"],"URL":"https:\/\/doi.org\/10.1111\/jdv.70738","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,13]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jdv.70738"}}