{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:09:50Z","timestamp":1790856590203,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273549"],"award-info":[{"award-number":["82273549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["SBK2022023090"],"award-info":[{"award-number":["SBK2022023090"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitiligo is a complex autoimmune skin disorder influenced by genetic susceptibility and environmental factors. Psychiatric morbidity has been proposed as a potential antecedent or correlate of vitiligo, but its prospective association with incident vitiligo remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the prospective association between psychiatric morbidity and vitiligo and determine the extent to which this association is modified by genetic susceptibility, quantified by polygenic risk scores (PRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 379,589 UK Biobank participants. Psychiatric morbidity and vitiligo were ascertained using ICD\u201010 codes. A vitiligo\u2010specific PRS was analysed as elevated versus non\u2010elevated genetic risk. Cox proportional hazards models were employed to evaluate associations, followed by interaction and exploratory pathway analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median follow\u2010up of 13.6\u2009years, anxiety (HR 1.78, 95% CI 1.23\u20132.56) and depression (HR 1.46, 95% CI 1.03\u20132.06) were associated with incident vitiligo in the fully adjusted model. Elevated PRS was associated with higher vitiligo risk (HR 1.48, 95% CI 1.17\u20131.88). Stratified analyses revealed heterogeneous effects of psychiatric morbidity across genetic backgrounds. Participants with both psychiatric morbidity and elevated PRS had the highest point estimate (HR 2.28, 95% CI 1.06\u20134.88). Exploratory pathway analyses suggested lymphocyte percentage as a possible immune\u2010related marker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hospital\u2010recorded psychiatric morbidity and elevated genetic susceptibility were prospectively associated with incident vitiligo. These observational findings support consideration of mental health in holistic vitiligo care, while causal mechanisms require independent validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70764","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:53:43Z","timestamp":1790855623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychiatric morbidity, genetic susceptibility and the risk of vitiligo"],"prefix":"10.1111","author":[{"given":"Yongkai","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital  Nanjing Jiangsu 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