{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:43:55Z","timestamp":1792068235308,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is associated with obesity, metabolic dysfunction and increased healthcare utilization. Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) have demonstrated anti\u2010inflammatory effects and reduction in HS symptoms, but real\u2010world patterns of GLP\u20101RA use in HS remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate GLP\u20101RA use and comorbidity burden among patients with HS compared to matched psoriasis patients and background controls, including changes in healthcare utilization and treatment patterns following GLP\u20101RA initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this nationwide Danish register\u2010based cohort study, adult patients with HS and age\u2010 and sex\u2010matched patients with psoriasis and background controls were included from 1 January 2000 to 31 December 2022. Comorbidities were assessed at the date of HS diagnosis (index date) and at GLP\u20101RA initiation. Healthcare utilization, surgical procedures and medication use were examined during the 2\u2009years before and after GLP\u20101RA initiation among patients with HS receiving continuous GLP\u20101RA treatment and matched HS non\u2010users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 12,581 patients with HS, 9824 patients with psoriasis, and 12,581 controls were included. During follow\u2010up, 8.2% of patients with HS initiated GLP\u20101RA treatment, compared with 5.7% of psoriasis patients and 3.2% of controls. Mean time to GLP\u20101RA initiation was shorter among patients with HS (8.88\u2009years) than psoriasis patients (10.1\u2009years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and controls (10.2\u2009years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cardiometabolic and psychiatric comorbidities increased from index date to treatment initiation across all groups. Following GLP\u20101RA initiation, lower rates of surgical procedures and systemic medication use were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with HS demonstrated earlier and more frequent use of GLP\u20101RA compared with psoriasis patients and controls, with decreased use of HS\u2010specific treatments and surgical procedures following GLP\u20101RA initiation. Comparable declines were observed among matched non\u2010initiators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70769","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:19:04Z","timestamp":1791022744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glucagon\u2010like peptide\u20101 receptor agonists in hidradenitis suppurativa: A nationwide cohort study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7395-6009","authenticated-orcid":false,"given":"Valdemar Wendelboe","family":"Nielsen","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Venereology &amp; Wound Healing Centre Copenhagen University Hospital \u2010 Bispebjerg &amp; Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-5188","authenticated-orcid":false,"given":"Nikolaj","family":"Holgersen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology &amp; Wound Healing Centre Copenhagen University Hospital \u2010 Bispebjerg &amp; Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2560-1922","authenticated-orcid":false,"given":"Nadja H\u00f8jgaard","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology &amp; Wound Healing Centre Copenhagen University Hospital \u2010 Bispebjerg &amp; Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3752-4114","authenticated-orcid":false,"given":"Emma","family":"Brogaard","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology &amp; Wound Healing Centre Copenhagen University Hospital \u2010 Bispebjerg &amp; Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-2815","authenticated-orcid":false,"given":"Yuki M. F.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology &amp; Wound Healing Centre Copenhagen University Hospital \u2010 Bispebjerg &amp; Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8257-1816","authenticated-orcid":false,"given":"Alexander","family":"Egeberg","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology &amp; Wound Healing Centre Copenhagen University Hospital \u2010 Bispebjerg &amp; Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health of Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-1743","authenticated-orcid":false,"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology &amp; Wound Healing Centre Copenhagen University Hospital \u2010 Bispebjerg &amp; Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-300X","authenticated-orcid":false,"given":"Simon Francis","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology &amp; Wound Healing Centre Copenhagen University Hospital \u2010 Bispebjerg &amp; Frederiksberg  Copenhagen Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2025.2373"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02475-9"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.3779"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.6264"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14225"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.691"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20472"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1800"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.02.023"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15233"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2023.11.007"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.11.039"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae216"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw213"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jvc2.70231"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010028116"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2025.2989"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad109"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1708853"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1826392"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20694"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2025.07.003"},{"issue":"1","key":"e_1_2_13_25_1","article-title":"Pain in hidradenitis Suppurativa: a cross\u2010sectional study of 1,795 patients","volume":"101","author":"Krajewski P","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.11.017"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.8926"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2025.05.004"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70769","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.70769","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:44:51Z","timestamp":1792064691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.70769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,3]]},"references-count":27,"alternative-id":["10.1111\/jdv.70769"],"URL":"https:\/\/doi.org\/10.1111\/jdv.70769","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,3]]},"assertion":[{"value":"2026-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jdv.70769"}}