{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:47:14Z","timestamp":1791877634354,"version":"4.3.4"},"reference-count":114,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nail unit melanoma (NUM) is a distinct form of melanoma that most often arises from the nail matrix. No recommendations as to the management of nail melanoma, particularly of early\u2010stage melanoma (in situ, stage IA, IB), exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To provide practical, experience\u2010based recommendations for the diagnosis, differential diagnosis and management of early\u2010stage NUM, developed by an international expert panel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on clinical and histopathological experience and an extensive literature search, the authors present recommendations for the management of patients with lesions suspicious for NUM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinically, most cases present as a longitudinal pigmented band in an adult nail. It represents 1.5\u20132.5% of all melanomas in Caucasians but up to 50% in Black patients. Considering that the nail unit surface area accounts for less than 1% of the total body surface, the nail matrix can be regarded as a hotspot for melanoma development. Early diagnosis is critical, as treatment at the in\u00a0situ or minimally invasive stage is associated with high cure rates. While dermoscopy is a useful diagnostic aid, nail matrix biopsy with histopathology remains the gold standard. Laboratory tests and standard imaging studies are not diagnostic; however, they may assist in surgical planning for advanced cases. Complete surgical excision is the treatment of choice. Wide local excision is recommended for early\u2010stage disease, with specific margins (6\u2009mm for standard lesions; 10\u2009mm in the presence of the Hutchinson sign). Amputation is generally reserved for thicker tumours (&gt;1\u2009mm). A 10\u2010year follow\u2010up period is recommended to monitor for potential recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early diagnosis and treatment of nail unit melanoma at the in\u00a0situ or minimally invasive stage (IA\/IB) are associated with high cure rates. In contrast, advanced disease with deep invasion or metastasis carries a poor prognosis\u2014therefore, timely recognition and intervention are essential to optimize outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70790","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:05:03Z","timestamp":1791875103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experience\u2010based recommendations for the diagnosis and management of early\u2010stage nail unit melanoma"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9957-1441","authenticated-orcid":false,"given":"Eckart","family":"Haneke","sequence":"first","affiliation":[{"name":"Department of Dermatology Inselspital, University of Berne  Bern 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