{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:04:09Z","timestamp":1754481849350,"version":"3.37.3"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NSF CAREER","award":["DEB-0845497"],"award-info":[{"award-number":["DEB-0845497"]}]},{"name":"NSF Doctoral Dissertation Improvement","award":["DEB-1110588"],"award-info":[{"award-number":["DEB-1110588"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Evolutionary Biology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Identifying the genetic basis of parallel phenotypic evolution provides insight into the process of adaptation and evolutionary constraint. White clover (<jats:italic>Trifolium repens<\/jats:italic>) has evolved climate\u2010associated adaptive clines in cyanogenesis (the ability to produce hydrogen cyanide upon tissue damage) in several world regions where it has been introduced. Gene\u2010deletion polymorphisms at the <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>79D15<\/jats:italic> and <jats:italic>Li<\/jats:italic> loci underlie the presence\/absence of the cyanogenic phenotype. Both loci have undergone multiple independent gene\u2010deletion events, which are identifiable through molecular signatures in flanking regions. To investigate whether cyanogenesis clines in introduced populations have evolved through the sorting of standing genetic variation or <jats:italic>de novo<\/jats:italic> gene deletions, we examined cyanogenesis gene\u2010flanking regions in three world regions. In comparison with native Eurasian populations, we find no evidence for novel gene deletion events in any introduced region, which suggests that these adaptive clines have evolved through the geographical sorting of pre\u2010existing genetic variation.<\/jats:p>","DOI":"10.1111\/jeb.12466","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T12:32:26Z","timestamp":1408624346000},"page":"2554-2558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adaptive cyanogenesis clines evolve recurrently through geographical sorting of existing gene deletions"],"prefix":"10.1093","volume":"27","author":[{"given":"N. 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