{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:53:42Z","timestamp":1761155622947},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and aim:<\/jats:bold> In Mainland China, heparin saline solution is commonly used for flushing and locking peripheral intravenous access devices in clinical practice for a long time. We conducted a prospective controlled trial to compare the effectiveness and safety of preservative\u2010free 0.9% sodium chloride solution versus heparin saline solution as flushing and locking solution for peripheral intravenous access devices.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Patients with gastroenterological or hepatic diseases were enrolled for this study from August 2011 to October 2011. After non\u2010randomized allocation, preservative\u2010free 0.9% sodium chloride was used as flushing and locking solution in the sodium chloride solution group, while hepatic solution (10 U\/mL) was given in the heparin saline solution group. The device related complications and its maintenance duration were compared between two groups. One\u2010way ANOVA, Chi<jats:sup>2<\/jats:sup>, or Mantel\u2010Haenszel test were performed using SPSS 13.0 and RevMan 5.0.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Totally, 181 and 178 peripheral intravenous access devices in the sodium chloride solution and heparin saline solution groups were included and analyzed. Results indicated than sodium chloride solution did not increase the risks of occlusion (7.7% vs. 7.9%) and other adverse events of peripheral intravenous access devices (P = 0.163). Sodium chloride solution neither shortened the duration of peripheral intravenous access devices maintenance (3.6 \u00b1 1.1 days vs. 3.7 \u00b1 1.2 days, P = 0.651), nor increased the proportion of abnormal withdrawal (29.3% vs. 31.5%, P = 0.654).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Sodium chloride solution is as effective and safe as conventional heparin saline solution for flushing and locking peripheral intravenous access devices, which results from our evidence\u2010based study and should be transferred to other nurses in China.<\/jats:p>","DOI":"10.1111\/jebm.12004","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T10:21:48Z","timestamp":1351765308000},"page":"205-208","source":"Crossref","is-referenced-by-count":17,"title":["Preservative\u2010free 0.9% sodium chloride for flushing and locking peripheral intravenous access device: a prospective controlled trial"],"prefix":"10.1111","volume":"5","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ou","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Guang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"issue":"1","key":"e_1_2_6_2_2","first-page":"S1","article-title":"Infusion nursing standards of practice","volume":"34","author":"Infusion Nurses Society","year":"2011","journal-title":"Journal of Infusion Nursing"},{"issue":"9","key":"e_1_2_6_3_2","first-page":"78","article-title":"Development of sealing technique for venous catheter","volume":"20","author":"Wang Y","year":"2005","journal-title":"Journal of Nursing Science"},{"issue":"15","key":"e_1_2_6_4_2","first-page":"104","article-title":"Effect of heparin sodium solution of different concentration in sealing up the tube of intravenous indwelling needle in children","volume":"1","author":"Huang WY","year":"2011","journal-title":"China Medicine and Pharmacy"},{"issue":"8","key":"e_1_2_6_5_2","first-page":"2013","article-title":"Influence of different doses of heparin in sealing\u2010tube fluids on bleeding and blood coagulation mechanisms of old patients","volume":"21","author":"Huang MX","year":"2007","journal-title":"Chinese Nursing Research"},{"issue":"2","key":"e_1_2_6_6_2","first-page":"32","article-title":"Comparison of the sealing effects of vein permanent needle between normal saline and natrium heparin","volume":"6","author":"Jiang GF","year":"2009","journal-title":"Nursing Practice and Research"},{"issue":"14","key":"e_1_2_6_7_2","first-page":"1427","article-title":"Effectiveness of two kinds locking solution for peripheral intravenous catheter","volume":"30","author":"Huang WX","year":"2009","journal-title":"Jilin Medical Journal"},{"issue":"6","key":"e_1_2_6_8_2","first-page":"626","article-title":"Efficacy of 0.9% sodium chloride injection with and without heparin for maintaining indwelling intermittent injection sites","volume":"3","author":"Epperson EL","year":"1984","journal-title":"Clinical Pharmacology"},{"issue":"6","key":"e_1_2_6_9_2","first-page":"439","article-title":"Heparin sodium versus 0.9% sodium chloride injection for maintaining patency of indwelling intermittent infusion devices","volume":"7","author":"Hamilton RA","year":"1988","journal-title":"Clinical Pharmacology"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0897-1897(05)80077-1"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0b013e31821bab61"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e31823312b1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31824e11b4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2009.05103.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/175045890801801003"},{"issue":"7","key":"e_1_2_6_16_2","first-page":"39","article-title":"Efficacy and safety of two kinds of tube\u2010sealing solution for intravenous catheter needle","volume":"19","author":"Gai QY","year":"2012","journal-title":"Journal of Nursing"}],"container-title":["Journal of Evidence-Based Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjebm.12004","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjebm.12004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.12004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:49:29Z","timestamp":1700567369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jebm.12004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/jebm.12004"],"URL":"https:\/\/doi.org\/10.1111\/jebm.12004","archive":["Portico"],"relation":{},"ISSN":["1756-5383","1756-5391"],"issn-type":[{"value":"1756-5383","type":"print"},{"value":"1756-5391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}