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In many scientific disciplines involving decision and control, this process has been significantly improved by making it as a system (a set of interacting entities forming an integrated whole).<\/jats:p><jats:p>Hypothesizing that most medical decisions can be described as a system, we present a schematic systematic loop, based on four traditional medical steps (nosology, semeiology, pathophysiology, and therapy), and on the four transitions between these steps. Steps are evaluated by reproducibility, transitions are evaluated by predictability. This leads to formulate eight basic questions for testing the reliability of any loop. We applied this approach to a specific study (EPHESUS) to show its interest in the control of the medical knowledge provided by a study and in indicating where evidence is missing.<\/jats:p><jats:p>A systematic approach helps evidence\u2010based medicine in structuring evidences for better medical decisions and in determining which research needs priority.<\/jats:p>","DOI":"10.1111\/jebm.12037","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T07:07:30Z","timestamp":1369811250000},"page":"109-114","source":"Crossref","is-referenced-by-count":3,"title":["Systematic approach: an evidence management strategy for better decision\u2010making"],"prefix":"10.1111","volume":"6","author":[{"given":"Pierre","family":"Squara","sequence":"first","affiliation":[{"name":"CERIC Clinique Ambroise Par\u00e9  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