{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:59:36Z","timestamp":1740153576681,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T00:00:00Z","timestamp":1377561600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2009CB522401"],"award-info":[{"award-number":["2009CB522401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81273255"],"award-info":[{"award-number":["81273255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postoperative infections and rejection are the main limiting factors of small intestine allograft survival. In this study, we performed a systematic review and meta\u2010analysis to review rat small intestine allograft survival following infusion of tolerance dendritic cells (Tol\u2010DCs) induced by different methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relevant publications were searched from PubMed database and EMbase database. Meta\u2010analysis was performed using RevMan 5.0 software. We chose allograft survival, mixed leukocyte reaction, Th1\/Th2 differentiation, Treg induction, and cytotoxic T lymphocyte activity as the outcomes by which to examine possible mechanisms that promote survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven suitable articles were identified and assessed. Tol\u2010DCs induced by four methods all prolonged allograft survival. The difference in survival time between the Tol\u2010DC group and the control group was indicated by SMD as follows: drug intervention (SMD = 3.02, 95% CI 1.16 to 4.88, P = 0.001), gene modification (SMD = 2.43, 95% CI 1.77 to 3.10, P &lt; 0.00001), imDC (SMD = 1.76, 95% CI 0.90 to 2.62, P &lt; 0.0001), cytokine induction (SMD = 1.68, 95% CI 0.40 to 2.96, P = 0.01). Tol\u2010DCs were also synergistic with immunosuppressive drugs or costimulation inhibitors, but no immune tolerance was observed. A single\u2010dose intravenous injection of 5\u00d710<jats:sup>6<\/jats:sup> to 6\u00d710<jats:sup>6<\/jats:sup> Tol\u2010DCs showed the highest allograft survival. Possible mechanisms included donor\u2010specific T\u2010cell hyporesponsiveness and Th2 differentiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrated that Tol\u2010DCs induced by four methods prolong rat small intestine allograft survival. Intravenous infusion of 5\u00d710<jats:sup>6<\/jats:sup> to 6\u00d710<jats:sup>6<\/jats:sup> Tol\u2010DCs was the optimum dose in rat small intestine transplantation. Immunosuppressive or costimulatory blockade was synergistic with Tol\u2010DC on graft survival. Additional high\u2010quality studies with larger sample sizes are needed to better investigate small intestinal graft longer term survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12050","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T11:51:20Z","timestamp":1375271480000},"page":"185-196","source":"Crossref","is-referenced-by-count":5,"title":["Adoptive infusion of tolerance dendritic cells prolongs survival of small intestine allografts in rats: systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"6","author":[{"given":"Guixiang","family":"Sun","sequence":"first","affiliation":[{"name":"Key Laboratory of Transplant Engineering and Immunology of Health Ministry of China West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Shan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Transplant Engineering and Immunology of 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