{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:37:26Z","timestamp":1767976646815,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:00:00Z","timestamp":1401321600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To systematically review the effects of tolerogenic dendritic cells (Tol\u2010DCs) induced by different methods on liver transplantation and their possible mechanisms of action.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed and EMbase were searched for relevant articles through 31 December 2013. The effects of Tol\u2010DCs on liver allograft survival were semiquantitatively evaluated, and the possible mechanisms by which Tol\u2010DCs prolong graft survival were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven articles were included, and classified according to methods of induction, sources, and methods of infusing Tol\u2010DCs. Tol\u2010DCs induced from immature DCs (imDCs), with cytokines, and by gene modification induced liver transplant tolerance for 33.1 \u00b1 32.5 days (2.7\u2010fold vs. control), 26.17 \u00b1 16.20 days (1.8\u2010fold vs. control), and 11.7 \u00b1 1.6 days (2.3\u2010fold vs. control), respectively. DCs derived from recipient bone marrow, donor bone marrow, and donor spleen induced liver transplant tolerance for 51.0 \u00b1 0.0 days (5.9\u2010fold vs. control), 21.4 \u00b1 26.8 days (2.4\u2010fold vs. control), and 15.0 \u00b1 0.0 days (2.3\u2010fold vs. control), respectively. The primary mechanisms by which Tol\u2010DCs induce liver transplant tolerance were the induction of T\u2010cell hyporeactivity and Th2 differentiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tol\u2010DCs induced by three different methods could extend liver allograft survival, with imDCs showing optimal results. The optimal infusion method was intravenous injection of 1\u20132 \u00d7 10<jats:sup>6<\/jats:sup> Tol\u2010DC, similar to findings in renal transplantation. Tol\u2010DCs prolonged liver transplant tolerance more than renal transplant tolerance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12094","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T12:17:30Z","timestamp":1393849050000},"page":"135-146","source":"Crossref","is-referenced-by-count":14,"title":["Adoptive transfusion of tolerogenic dendritic cells prolongs the survival of liver allograft: a systematic review"],"prefix":"10.1111","volume":"7","author":[{"given":"Meng Juan","family":"Xia","sequence":"first","affiliation":[{"name":"Key Laboratory of Transplant Engineering and Immunology of National Health and Family Planning Commission of the People's Republic of China Regenerative Medical Research Center West China Hospital  Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Shan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Transplant Engineering and Immunology of National Health and Family Planning Commission of the People's Republic of China Regenerative Medical Research Center West China Hospital  Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Transplant Engineering and Immunology of National Health and Family Planning Commission of the People's Republic of China Regenerative Medical Research Center West China Hospital  Sichuan University Chengdu China"},{"name":"Chinese Cochrane Centre Chinese Evidence\u2010Based Medicine Centre  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan Ni","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Transplant Engineering and Immunology of National Health and Family Planning Commission of the People's Republic of China Regenerative Medical Research Center West China Hospital  Sichuan University Chengdu 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People's Republic of China Regenerative Medical Research Center West China Hospital  Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Transplant Engineering and Immunology of National Health and Family Planning Commission of the People's Republic of China Regenerative Medical Research Center West China Hospital  Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9681-4"},{"key":"e_1_2_8_3_1","first-page":"659","article-title":"Homotransplantation of the liver in humans","volume":"117","author":"Starzl TE","year":"1963","journal-title":"Surgery, Gynecology & 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