{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:55:52Z","timestamp":1768269352158,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The treatment of cutaneous leishmaniasis is toxic, has contraindications, and a high cost. The objective of this study was to estimate the cost\u2010effectiveness of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Effectiveness was the proportion of healing and safety with the adverse effects; these parameters were estimated from a controlled clinical trial and a meta\u2010analysis. A standard costing was conducted. Average and incremental cost\u2010effectiveness ratios were estimated. The uncertainty regarding effectiveness, safety, and costs was determined through sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total costs were $66,807 with Glucantime and $14,079 with thermotherapy. The therapeutic effectiveness rates were 64.2% for thermotherapy and 85.1% for Glucantime. The average cost\u2010effectiveness ratios ranged between $721 and $1275 for Glucantime and between $187 and $390 for thermotherapy. Based on the meta\u2010analysis, thermotherapy may be a dominant strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The excellent cost\u2010effectiveness ratio of thermotherapy shows the relevance of its inclusion in guidelines for the treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12245","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T04:52:38Z","timestamp":1486356758000},"page":"81-90","source":"Crossref","is-referenced-by-count":7,"title":["Cost\u2010effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis"],"prefix":"10.1111","volume":"10","author":[{"given":"Jaiberth Antonio","family":"Cardona\u2010Arias","sequence":"first","affiliation":[{"name":"School of Medicine Cooperative University of Colombia  Medell\u00edn Colombia"},{"name":"School of Microbiology University of Antioquia  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"L\u00f3pez\u2010Carvajal","sequence":"additional","affiliation":[{"name":"PECET University of Antioquia  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mery Patricia","family":"Tamayo Plata","sequence":"additional","affiliation":[{"name":"School of Economics and Finance EAFIT University  Medellin Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n Dar\u00edo","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"PECET University of Antioquia  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Instituto Nacional de Salud de Colombia Ministerio de la Protecci\u00f3n Social Rep\u00fablica de Colombia Organizaci\u00f3n Panamericana de la Salud. Protocolo para la vigilancia en salud p\u00fablica de Leishmaniasis.2011.http:\/\/www.ins.gov.co\/temas-de-interes\/Leishmaniasis%20viceral\/01%20protocolo%20Leishmaniasis.pdf. Accessed 10 October 2013."},{"key":"e_1_2_7_3_1","unstructured":"WHO (World Health Organization).Control of the leishmaniases. Technical Report Series 949 .Geneva;2010."},{"key":"e_1_2_7_4_1","unstructured":"EcheverryM GaonaJ GaulteroS et\u00a0al.Gu\u00eda de atenci\u00f3n de la leishmaniasis.2011[Internet].http:\/\/www.acin.org\/acin\/new\/Portals\/0\/Templates\/Guia%20Leishmania.pdf. 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