{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:27:38Z","timestamp":1746332858236},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shanghai Green Valley Pharmaceutical Co., Ltd","award":["H1511103"],"award-info":[{"award-number":["H1511103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore patient characteristics associated with treatment response in patients receiving salvianolate injection for stable angina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An analysis was conducted of data from a multicenter, phase IV clinical trial undertaken in China that enrolled 2150 patients hospitalized for stable angina from 50 hospitals. The treatment outcomes were changes of angina severity and nitroglycerin use between baseline and the last day of treatment. We used logistic regression models to explore patient characteristics associated with the treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients who were overweight or obese (OR<jats:sub>a<\/jats:sub> 1.20, 95% CI 1.01 to 1.44), present with hypertension (OR<jats:sub>a<\/jats:sub> 1.23, 95% CI 1.01 to 1.49), experienced with 3 or more episodes of angina per week (OR<jats:sub>a<\/jats:sub> 1.77, 95% CI 1.44 to 2.17), or concomitantly using antiplatelet agents (OR<jats:sub>a<\/jats:sub> 1.44, 95% CI 1.17 to 1.78) were associated with better treatment response defined with the change of angina severity. Those of overweight or obesity (OR<jats:sub>a<\/jats:sub> 1.57, 95% CI 1.17 to 2.12) or concomitantly using calcium antagonists (OR<jats:sub>a<\/jats:sub> 2.38, 95% CI 1.39 to 4.08) fared better treatment response according to discontinuation or reduction of nitroglycerin use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients diagnosed with stable angina and receiving salvianolate injection might fare better treatment response if they were overweight or obese, experienced with hypertension, three or more episodes of angina per week, or concomitantly using antiplatelet agents and calcium antagonists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12282","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T05:54:13Z","timestamp":1515650053000},"page":"83-88","source":"Crossref","is-referenced-by-count":7,"title":["Patient characteristics associated with treatment response in patients receiving salvianolate injection for stable angina"],"prefix":"10.1111","volume":"11","author":[{"given":"Yana","family":"Qi","sequence":"first","affiliation":[{"name":"Chinese Evidence\u2010based Medicine Center West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Chinese Evidence\u2010based Medicine Center West China Hospital Sichuan University  Chengdu China"},{"name":"West China School of Public Health Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Chinese Evidence\u2010based Medicine Center West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Evidence\u2010based Medicine Center West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61097-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60921-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0786"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.11.030"},{"key":"e_1_2_8_6_1","first-page":"3186","article-title":"Analysis of salvianolate injection combined with usual drugs in treatment of coronary heart disease in real world","volume":"38","author":"Chang YP","year":"2013","journal-title":"Zhongguo zhong yao za zhi"},{"key":"e_1_2_8_7_1","first-page":"3462","article-title":"Symptoms of TCM diagnosis and analysis of Chinese and western medicine treating 84697 cases with coronary heart disease","volume":"39","author":"Li GH","year":"2014","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.02.016"},{"key":"e_1_2_8_9_1","first-page":"55","article-title":"Effect of depside salt from salvia miltiorrhiza on angina pectoris and platelet function","volume":"12","author":"Yan P","year":"2004","journal-title":"J Interventional Radiology"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"140","article-title":"Clinical observation on saivianolate for the treatment of angina pectoris in coronary heart disease with heart\u2010blood stagnation syndrome","volume":"17","author":"Miao Y","year":"2006","journal-title":"Traditional Chinese Drug Research & Clinical Pharmacology"},{"key":"e_1_2_8_11_1","first-page":"3092","article-title":"Real world study of effect on liver function of overdose of salvianolate extract injection","volume":"38","author":"Chang YP","year":"2013","journal-title":"Zhongguo zhong yao za zhi"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.54.3.947585"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-8_Part_1-200110160-00014"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.05.044"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht296"},{"key":"e_1_2_8_16_1","first-page":"195","article-title":"Guidelines for the diagnosis and treatment of Chronic stable angina pectoris","volume":"35","author":"Chinese Society of Cardiology, Editorial Board of Chinese Journal of Cardiology","year":"2007","journal-title":"Chin J Cardiol"},{"key":"e_1_2_8_17_1","first-page":"48","article-title":"Current status of medical therapy for chronic stable angina pectoris in China","volume":"35","author":"Wang XG","year":"2015","journal-title":"Chinese Journal of Practical Internal Medicine"},{"key":"e_1_2_8_18_1","first-page":"1060","article-title":"Current status of medical therapy of chronic stable angina pectoris in mainland of China: the second survey","volume":"38","author":"Research Group on treatment of angina pectoris","year":"2010","journal-title":"Chin J Cardiol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1981"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.134983"}],"container-title":["Journal of Evidence-Based Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjebm.12282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.12282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:22:12Z","timestamp":1695475332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jebm.12282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/jebm.12282"],"URL":"https:\/\/doi.org\/10.1111\/jebm.12282","archive":["Portico"],"relation":{},"ISSN":["1756-5383","1756-5391"],"issn-type":[{"value":"1756-5383","type":"print"},{"value":"1756-5391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]}}}