{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:11:59Z","timestamp":1787663519795,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71704120"],"award-info":[{"award-number":["71704120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the impact of motherwort injection alone or combined with oxytocin for preventing postpartum hemorrhage in pregnant women with caesarean section.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review and meta\u2010analysis of randomized trials were performed. PubMed, EMbase, The Cochrane Central Register of Controlled Trials (CENTRAL), Chinese database Sino\u2010Med, Chinese National Knowledge Infrastructure Database (CNKI), VIP Chinese Science and Technique Journals Database, WanFang, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> were searched. Randomized controlled trials (RCTs) that compared motherwort injection alone or motherwort injection combined with oxytocin in pregnant women receiving cesarean section were included. Paired reviewers independently screened abstracts and full texts for eligibility, assessed risk of bias, and extracted data. We performed random\u2010effects meta\u2010analyses of RCTs along with a limited number of prespecified subgroup hypotheses, and sensitivity analyses were carried out with other statistical approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six RCTs (<jats:italic>n\u00a0<\/jats:italic>=\u00a07359) proved eligible. Compared with oxytocin, both motherwort injection and motherwort injection combined with oxytocin had a significantly lower blood loss within 2\u00a0hours (MD\u00a0=\u00a0\u221221.81, 95% CI \u221237.05 to \u22126.58 and MD\u00a0=\u00a0\u221253.04, 95% CI \u221261.68 to \u221244.39); lower blood loss within 24\u00a0hours (MD\u00a0=\u00a0\u221225.44, 95% CI \u221239.38 to \u221211.51 and MD\u00a0=\u00a0\u221267.81, 95% CI \u221278.02 to \u221257.60); and lower the risk of adverse events (OR<jats:sub>Peto<\/jats:sub> 0.40, 95% CI 0.16 to 0.96 and OR<jats:sub>Peto<\/jats:sub> 0.50, 95% CI 0.35 to 0.71). Motherwort injection combined with oxytocin also decreased the risk of postpartum hemorrhage (OR 0.22, 95% CI 0.14 to 0.35.)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In pregnant women with cesarean section, motherwort injection suggests an obvious benefit and less adverse event.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12300","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T06:09:51Z","timestamp":1528438191000},"page":"252-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Motherwort injection for preventing postpartum hemorrhage in pregnant women with cesarean section: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"11","author":[{"given":"Wenwen","family":"Chen","sequence":"first","affiliation":[{"name":"Chinese Evidence\u2010Based Medicine Center West China Hospital, Sichuan University  Chengdu 610041 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