{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:16:55Z","timestamp":1771661815031,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Regional Health Authority of Umbria-Umbria Region"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this work was to summarize and update the evidence concerning oral iron\u2010based interventions compared to placebo or no iron\u2010based interventions to prevent critical outcomes in pregnancy or treat critical outcomes in the postpartum phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Published systematic reviews (Feb 2018) and primary studies (from 2015 to March 2018) retrieved from MEDLINE, EMBASE, and the Cochrane Library were examined. The AMSTAR (Assessing the Methodological Quality of Systematic Reviews) tool was used to assess the quality of reviews. GRADE was used to rate the quality of the evidence for critical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antenatal care: Compared to placebo\/no treatment, iron\u2010based therapies reduced maternal anemia at term by 59% (seven trials at low risk of bias, RR 0.41, 95% CI 0.23\u20100.73; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a086%; moderate\u2010quality evidence) and maternal iron deficiency anemia by 67% (RR 0.33, 95% CI 0.16\u20100.69; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a049%). There was no evidence of difference between iron\u2010based therapies vs control in terms of side effects (RR 1.42, 95% CI 0.91\u20102.21), preterm delivery (13 studies: RR 0.93, 95% CI 0.84\u20101.03; low\u2010quality evidence), low birthweight (RR 0.94, 95% CI 0.79\u20101.13; low\u2010quality evidence) and infant mortality (RR 0.93, 0.72\u20101.20; low\u2010quality evidence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Postnatal care<\/jats:title><jats:p>There was insufficient evidence to determine whether iron\u2010based therapies can reduce postpartum anemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iron supplementation is effective in preventing maternal anemia at term but not low birthweight, preterm delivery or infant mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12344","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T04:41:41Z","timestamp":1559191301000},"page":"155-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Oral iron\u2010based interventions for prevention of critical outcomes in pregnancy and postnatal care: An overview and update of systematic reviews"],"prefix":"10.1111","volume":"12","author":[{"given":"Iosief","family":"Abraha","sequence":"first","affiliation":[{"name":"Centro Regionale Sangue, Servizio Immunotrasfusionale Azienda Ospedaliera di Perugia  Perugia Italy"},{"name":"Health Planning Service Regional Health Authority of Umbria  Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabella","family":"Bonacini","sequence":"additional","affiliation":[{"name":"ABM University Health Board Advanced Pharmacist Technical Services  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