{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:50:29Z","timestamp":1787161829612,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In the face of an unclear causal association between Zika virus\n                      <jats:italic>in utero<\/jats:italic>\n                      exposure and congenital abnormalities and urgent demand for guidance, the World Health Organization (WHO) had to produce timely and trustworthy guidelines during the 2016 Public Health Emergency of International Concern (PHEIC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross\u2010sectional evaluation of WHO emergency guidelines produced during the Zika virus disease PHEIC from 1 February to 18 November 2016. We assessed adherence to WHO publication requirements and the reporting of guideline development processes associated with trustworthiness. In the absence of quality appraisal tools for guidelines developed under compressed timeframes, we applied the Appraisal of\u00a0Guidelines for\u00a0Research and\u00a0Evaluation (AGREE II) tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 21 guidelines (13 de novo and 8 updates). Six guidelines used a formal evidence review process. Most guidelines involved external experts in the development process and collected declarations of interest. Peer review was reported in six documents. Most emergency guidelines included updating plans. The highest scoring AGREE II domain was clarity of presentation (median score 78%); the lowest scoring domain was applicability (median score 18%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>WHO developed moderate\u2010 to high\u2010quality emergency guidelines in the challenging context of a PHEIC. We found improvement opportunities for WHO guideline development teams in the use of evidence to formulate recommendations, the collection of declarations of interest, reporting of conflicts of interest, and the use of existing WHO organizational quality assurance processes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.12347","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T05:26:27Z","timestamp":1560921987000},"page":"218-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An evaluation of WHO emergency guidelines for Zika virus disease"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0042-2452","authenticated-orcid":false,"given":"Susan L","family":"Norris","sequence":"first","affiliation":[{"name":"WHO Guidelines Review Committee Secretariat World Health Organization  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Louis","sequence":"additional","affiliation":[{"name":"WHO Guidelines Review Committee Secretariat World Health Organization  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5912-3767","authenticated-orcid":false,"given":"Veronica I","family":"Sawin","sequence":"additional","affiliation":[{"name":"WHO Guidelines Review Committee Secretariat World Health Organization  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0298-0711","authenticated-orcid":false,"given":"Teegwend\u00e9 V","family":"Porgo","sequence":"additional","affiliation":[{"name":"Department of Social and Preventative Medicine, Centre de Recherche du CHU de Qu\u00e9bec\u2014H\u00f4pital de l'Enfant\u2010J\u00e9sus Laval University  Quebec City Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk Hei Agnes","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of California  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Evidence\u2010Based Medicine Center of Lanzhou University, Chinese GRADE Center\u2014Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Ferri","sequence":"additional","affiliation":[{"name":"WHO Guidelines Review Committee Secretariat World Health Organization  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO.Zika Virus Classification Table Data as of 15 February 2018.http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/260419\/zika-classification-15Feb18-eng.pdf;jsessionid=4D68513997BB454F75826D2BABF4F73F?sequence=1(accessed 10 October 2018)."},{"key":"e_1_2_10_3_1","volume-title":"Microcephaly and Guillain\u2010Barre Syndrome situation report","author":"WHO","year":"2017"},{"key":"e_1_2_10_4_1","unstructured":"WHO.Zika Virus: Key facts 20 July 2018.https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/zika-virus(accessed 27 December 2018)."},{"key":"e_1_2_10_5_1","unstructured":"Pan American Organiztionandthe World Health Organization.Zika cases and congenital syndrome associated with Zika virus reported by countries and territories in the Americas 2015 \u2010 2018. Cumulative cases.https:\/\/www.paho.org\/hq\/index.php?option=com_docman&view=download&category_slug=cumulative-cases-pdf-8865&alias=43296-zika-cumulative-cases-4-january-2018-296&Itemid=270&lang=en(accessed 27 December 2018)."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602113"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1608612"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1602708"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0245-2016"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005531"},{"key":"e_1_2_10_11_1","unstructured":"World Health Organization.WHO Zika Strategic Response Plan Revised for July 2016\u2010December. Geneva Switzerland: WHO Press;2016."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198125"},{"key":"e_1_2_10_13_1","volume-title":"WHO Handbook for Guideline Development (2nd edition)","author":"World Health Organization","year":"2014"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082915"},{"key":"e_1_2_10_15_1","volume-title":"Clinical Practice Guidelines We Can Trust","author":"Institutes of Medicine","year":"2011"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.091714"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.091716"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.090449"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2014.01.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002207"}],"container-title":["Journal of Evidence-Based Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjebm.12347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.12347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jebm.12347","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.12347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T12:36:25Z","timestamp":1694262985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jebm.12347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/jebm.12347"],"URL":"https:\/\/doi.org\/10.1111\/jebm.12347","archive":["Portico"],"relation":{},"ISSN":["1756-5383","1756-5391"],"issn-type":[{"value":"1756-5383","type":"print"},{"value":"1756-5391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,18]]},"assertion":[{"value":"2019-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}