{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:10:08Z","timestamp":1774077008288,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify important explanatory variables of four patient\u2010reported outcomes (PROs): vision\u2010related quality of life (VRQoL), preference\u2010based health\u2010related quality of life (HRQoL), social support and community integration and depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study conducted at one ophthalmic practice in a hospital setting. Patients with a diagnosis of glaucoma or glaucoma suspect (<jats:italic>n<\/jats:italic>\u00a0=\u00a0250) were sequentially recruited. Patients with language restrictions were excluded. Data were collected through medical chart reviews and face\u2010to\u2010face interviews. The PROs were measured using validated tools. Candidate models for predicting PROs from explanatory variables were constructed using linear and logistic regression, as well as classification and regression trees. Through leave\u2010one\u2010out cross\u2010validation, the performance of each model was assessed in terms of mean absolute error.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Use of mobility aids, best corrected visual acuity (BCVA), income, and living arrangements were most predictive of VRQoL, social support, and community integration. Use of mobility aids was also most predictive of the presence of depressive symptoms, and BCVA with preference\u2010based HRQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although promising associations were discovered, the models based on commonly collected clinical variables had limited ability to accurately predict individual patient PROs. Thus, although this study identifies clinical and demographic variables that are most predictive of PROs, routine collection of PROs in clinical practice may be necessary to obtain a complete picture of the quality of life of glaucoma patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12369","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T12:29:25Z","timestamp":1579264165000},"page":"8-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Estimating patient\u2010reported outcomes for glaucoma management: A cross\u2010sectional study"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2727-0249","authenticated-orcid":false,"given":"Lavanya","family":"Uruthiramoorthy","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry Western University  London Canada"},{"name":"Lawson Health Research Institute  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy M.L.","family":"Hutnik","sequence":"additional","affiliation":[{"name":"Lawson Health Research Institute  London Ontario Canada"},{"name":"Department of Ophthalmology Ivey Eye Institute, St. Joseph's Health Care London  London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy N.","family":"Speechley","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry Western University  London Canada"},{"name":"Lawson Health Research Institute  London Ontario Canada"},{"name":"Department of Paediatrics Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monali S.","family":"Malvankar\u2010Mehta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry Western University  London Canada"},{"name":"Lawson Health Research Institute  London Ontario Canada"},{"name":"Department of Ophthalmology Ivey Eye Institute, St. Joseph's Health Care London  London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J","family":"Lizotte","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry Western University  London Canada"},{"name":"Department of Computer Science Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.00999.x"},{"key":"e_1_2_5_3_1","first-page":"61","article-title":"Patient\u2010reported outcomes (PROs) and patient\u2010reported outcome measures (PROMs)\u2014ProQuest","author":"Weldring T","year":"2003","journal-title":"Health Serv Insights"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S45248"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0333-6"},{"key":"e_1_2_5_6_1","volume-title":"The Measurement of Health and Health Status: Concepts, Methods and Applications from a Multidisciplinary Perspective","author":"Krabbe P","year":"2016"},{"key":"e_1_2_5_7_1","volume-title":"The Impact of Vision Loss, Making Eye Health a Population Health Imperative: Vision for Tomorrow","author":"National Academies of Sciences, Engineering, and Medicine","year":"2016"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000445"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000393"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5935\/0034-7280.20150028"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.4908"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.73693"},{"issue":"1","key":"e_1_2_5_13_1","first-page":"S7","article-title":"Canadian Ophthalmological Society evidence\u2010based clinical practice guidelines for the management of glaucoma in the adult eye","volume":"44","author":"Canadian Ophthalmological Society Glaucoma Clinical Practice Guideline Expert Committee & Canadian Ophthalmological Society","year":"2009","journal-title":"Can. 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