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The studies\u2019 overall risk of bias was assessed as low in only 27% of the studies. In 282 studies, 29 out of 36 drug combinations and 10 out of 28 single drugs lowered the risk of vomiting at least 20% compared to placebo. In the ranking of treatments, combinations of drugs were generally more effective than single drugs. Single NK<jats:sub>1<\/jats:sub> receptor antagonists were as effective as other drug combinations. Of the 10 effective single drugs, certainty of evidence was high for aprepitant, ramosetron, granisetron, dexamethasone, and ondansetron, while moderate for fosaprepitant and droperidol. For serious adverse events (SAEs), any adverse event (AE), and drug\u2010class specific side effects evidence for intervention effects was mostly not convincing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is high or moderate evidence for at least seven single drugs preventing postoperative vomiting. However, there is still considerable lack of evidence regarding safety aspects that does warrant investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12429","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T18:48:56Z","timestamp":1622141336000},"page":"188-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Drugs for preventing postoperative nausea and vomiting in adults after general anesthesia: An abridged Cochrane network meta\u2010analysis"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1900-2535","authenticated-orcid":false,"given":"Stephanie","family":"Weibel","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine University Hospital Wuerzburg  Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan L.","family":"Pace","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian S.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care &amp; Pain Medicine, Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Anaesthesiology University Hospital Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care Medicine and Pain Medicine Queen Elizabeth University Hospital  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine University Hospital Wuerzburg  Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Meybohm","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine University Hospital Wuerzburg  Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kienbaum","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University Hospital Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopold H. 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