{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:15:16Z","timestamp":1791476116405,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2022,6]]},"abstract":"Abstract<\/jats:title>Clinical question<\/jats:title>The detection rate of the solitary pulmonary nodule (SPN) is increasing with the popularization of CT scanning. Malignancy risk stratification for SPN is a major clinical difficulty.<\/jats:p><\/jats:sec>Current practice<\/jats:title>There have been several guidelines for SPN assessment. Inconsistency of these guidelines makes the clinical application difficult and confusing.<\/jats:p><\/jats:sec>Recommendations<\/jats:title>In this Rapid Recommendation, solid and subsolid SPNs are recommended to be evaluated respectively. Six factors, namely the combination of age with sex, smoking history, history of malignancy, family history of malignancy, and nodule size, are recommended for malignancy risk stratification for both kinds of SPNs; the border of nodules (spiculation and lobulation) is recommended for evaluating solid SPNs and the density of nodules (pure or mixed ground\u2010glass nodule) is recommended for subsolid nodules. Among them, smoking history and radiologic features (nodule diameter, border, and density) are of relatively higher importance. A scoring system was proposed to assist malignancy risk stratification of SPNs, with a total score ranging from six points to 15 points (if solid) or 17 points (if subsolid). For each SPN, regardless of solid or subsolid in nature, a total score of \u2264 7 points suggested a low risk of being malignant, while 7 to 9 points suggested medium risk, and \u2265 9 points suggested high risk.<\/jats:p><\/jats:sec>How this guideline was created<\/jats:title>This rapid recommendation was developed using the MAGIC (Making GRADE the Irresistible Choice) methodological framework. First, a clinical subcommittee identified the topic of recommendation and requested evidence. Then, an independent evidence synthesis subcommittee performed a comprehensive literature review and evaluated the evidence. Finally, based on findings from the systematic review and use of real\u2010world data, the clinical subcommittee formulated recommendations, including the scoring system, through a consensus procedure.<\/jats:p><\/jats:sec>The evidence<\/jats:title>A total of 13857 patients with SPNs were included in the meta\u2010analysis and the association between 12 candidate factors and the risk of SPNs being malignant was studied. Eventually, seven factors were recommended for SPNs evaluation, and a scoring system was proposed.<\/jats:p><\/jats:sec>Understanding the recommendation<\/jats:title>The parameters included are objective. Therefore, this recommendation is feasible in clinical practice. However, there are several uncertainties, such as a lack of further verification. It might be misclassified by the scoring system. Clinicians could choose the most suitable scheme according to the recommendation, along with their own experience in specific situations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12476","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T12:56:34Z","timestamp":1656680194000},"page":"142-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Malignancy risk stratification for solitary pulmonary nodule: A clinical practice guideline"],"prefix":"10.1111","volume":"15","author":[{"given":"Bojiang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine West China Hospital of Sichuan University Chengdu China"},{"name":"Frontiers Science Center for Disease\u2010related Molecular Network West China Hospital Sichuan University Chengdu 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