{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:27:41Z","timestamp":1784356061165,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T00:00:00Z","timestamp":1659830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC1498"],"award-info":[{"award-number":["2022NSFSC1498"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate twin reversed arterial perfusion (TRAP) sequence for the prediction of TRAP\u2010related adverse pregnancy outcomes at the gestational age of 11\u201314\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant women in the first trimester diagnosed with TRAP were recruited at West China Second University Hospital from January 2015 to June 2018. Systematic screening for the pump twin's crown\u2010rump length (CRL) and acardiac twin's upper pole\u2010rump length (URL) was conducted using ultrasonic detection. The (CRL\u00a0\u2013 URL)\/CRL and URL\/CRL ratios were used to assess the pregnancy outcomes for the pump twin. Twenty\u2010one pregnant women aged 21\u201339\u00a0years with a gestation of 11\u201314\u00a0weeks were recruited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TRAP was diagnosed on average\u00a0(\u00b1\u00a0standard deviation (SD)) at pregnancy week 13.1\u00a0\u00b1\u00a00.18. The pump twins\u2019 mean\u00a0(\u00b1\u00a0SD) CRL was 6.65\u00a0\u00b1\u00a01.1\u00a0cm. The incidence of intrauterine death for the pump twins was 19.0% (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), the miscarriage rate was 14.3% (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), and the live birth rate was 66.7% (<jats:italic>n<\/jats:italic>\u00a0=\u00a014). The (CRL\u00a0\u2013 URL)\/CRL ratios between the nonsurvival (intrauterine death and miscarriage) and survival groups significantly differed (0.33\u00a0\u00b1\u00a00.08\u00a0vs. 0.58\u00a0\u00b1\u00a00.08, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Similarly, the URL\/CRL ratios between the nonsurvival and survival groups significantly differed (0.67\u00a0\u00b1\u00a00.08\u00a0vs. 0.42\u00a0\u00b1\u00a00.08, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The (CRL\u00a0\u2013 URL)\/CRL and URL\/CRL ratios were valuable indicators for determining pregnancy outcomes of pump twins with TRAP at an early gestational age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12488","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T03:22:12Z","timestamp":1659928932000},"page":"230-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ultrasound assessment of twin reversed arterial perfusion sequence for the prediction of adverse pregnancy outcomes in the first trimester"],"prefix":"10.1111","volume":"15","author":[{"given":"Ying","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Ultrasonography, West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education Sichuan University  Chengdu China"},{"name":"Department of Pediatrics, West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taizhu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Bao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education Sichuan University  Chengdu China"},{"name":"Department of Pediatrics, West China Second University Hospital Sichuan University  Chengdu 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