{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:20:02Z","timestamp":1778894402326,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have addressed the relationship of human papillomavirus (HPV) biotypes to patient characteristics and the clinical signs, course, and response to the treatment of plantar warts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Analyze the HPV types associated with plantar warts and their relationship with warts characteristics, patient characteristics and response to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 372 patients sampled for hyperkeratosis of a plantar wart were included. Multiplex polymerase chain reaction (PCR) was performed to detect the HPV biotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of HPV was 81.2%, and HPV1 was the most prevalent biotype (36.1%). HPV1 was the most prevalent biotype in patients\u00a0&lt;\u00a070 years old (90.9% in\u00a0&lt;\u00a010 years), and biotypes 2, 19 and 27 were the most prevalent in patients\u00a0&gt;\u00a070 years old (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012). HPV1 was the most frequent in patients with one (39,9%) or two (47.1%) warts and HPV5 (33.3%) in patients with three warts (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Cure, spontaneous resolution, and recurrence were higher in HPV1 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). HPV14 warts healed the fastest (2 months quartile 1\u20133 (2.0\u20132.0)), and HPV5 (10.977 (6.0\u201320.0)) and HPV27 (7.5 (3.0\u201310.0)) warts (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.033) took the longest to heal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HPV biotype is associated with age and the number of warts and appears to influence the natural history of warts and their response to treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12584","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T13:38:10Z","timestamp":1706881090000},"page":"10-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does HPV biotype influence the characteristics and evolution of plantar warts?"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-7122","authenticated-orcid":false,"given":"Sara","family":"Garc\u00eda\u2010Oreja","sequence":"first","affiliation":[{"name":"Cl\u00ednica Universitaria de Podolog\u00eda, Facultad de Enfermer\u00eda, Fisioterapia y Podolog\u00eda Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4674-3822","authenticated-orcid":false,"given":"Francisco Javier","family":"\u00c1lvaro\u2010Afonso","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universitaria de Podolog\u00eda, Facultad de Enfermer\u00eda, Fisioterapia y Podolog\u00eda Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-2194","authenticated-orcid":false,"given":"David","family":"Sevillano\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Microbiology Section Medical Faculty, Complutense University of Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3896-7079","authenticated-orcid":false,"given":"Esther Alicia","family":"Garc\u00eda\u2010Morales","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universitaria de Podolog\u00eda, Facultad de Enfermer\u00eda, Fisioterapia y Podolog\u00eda Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7342-059X","authenticated-orcid":false,"given":"Mateo","family":"L\u00f3pez\u2010Moral","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universitaria de Podolog\u00eda, Facultad de Enfermer\u00eda, Fisioterapia y Podolog\u00eda Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-0265","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"L\u00e1zaro\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universitaria de Podolog\u00eda, Facultad de Enfermer\u00eda, Fisioterapia y Podolog\u00eda Universidad Complutense de Madrid  Madrid 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