{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:43:46Z","timestamp":1787240626481,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Thiazides are the first\u2010line treatment for hypertension, however, they have been associated with hospitalizations for thiazide\u2010associated hyponatremia (TAH). The aim of this study was to evaluate the risk of TAH and other drug\u2010associated hyponatremia in a Korean population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study used big data from the National Health Insurance Sharing Service of 1,943,345 adults treated for hypertension from January 2014 to December 2016. The participants were divided into two groups based on the use of thiazides. Cox proportional hazard models were used to identify independent risk factors for the occurrence of hyponatremia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study found that hyponatremia\u2010related hospitalizations were significantly higher in the thiazide group than the control group (2.19%\u00a0vs. 1.45%). The risk increased further with concurrent use of other diuretics or desmopressin, and thiazide+spironolactone+desmopressin and hospitalization risk further increased (4.0 and 6.9 times). Multivariate analysis showed that hyponatremia occurrence increased with age, diabetes mellitus, depression, and thiazide use (hazard ratio\u00a0=\u00a01.436,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). The thiazide group had better 6\u2010year overall survival than the control group but had more fractures and hyponatremia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thiazide use is associated with an increased risk of hyponatremia and related complications. However, the mortality rate decreased in those who received thiazides, suggesting that thiazide use itself is not harmful and may help decrease complications and improve prognosis with proper, cautious use in high\u2010risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.12601","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:29:45Z","timestamp":1712104185000},"page":"296-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Thiazide\u2010associated hyponatremia in arterial hypertension patients: A nationwide population\u2010based cohort study"],"prefix":"10.1111","volume":"17","author":[{"given":"Soie","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasung","family":"Kim","sequence":"additional","affiliation":[{"name":"Data Science Team Hanmi Pharm. Co., Ltd  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungkuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Data Science Team Hanmi Pharm. Co., Ltd  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungho","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University Hospital  Seoul Republic of Korea"},{"name":"Department of Internal Medicine Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Internal Medicine Chung\u2010Ang University Gwangmyeong Hospital  Gyeonggi Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0829-0922","authenticated-orcid":false,"given":"Jin Ho","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang 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