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Low sodium salt, a mixture of mainly sodium chloride and potassium chloride, has shown its great potential as a promising population strategy for sodium intake reduction through multiple large\u2010scale, multicenter, randomized controlled trials among populations including patients with cardiovascular disease, individuals with and without hypertension, older and younger adults, and men and women in China and other countries. This Guidelines aims to provide expert recommendations for promotion and use of low sodium salt in China, based on the current available scientific evidence regarding the effectiveness, safety, cost\u2010effectiveness, and acceptability of low sodium salts in various population groups and different application scenarios. The suggestions to key stakeholders are also made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A working group, an expert review committee and an advisory committee were established to be responsible for formulating the guidelines\u2019 scope and key questions to be addressed, for searching, synthesizing, and evaluating research evidence, proposing and reviewing the recommendations. The consensus on the final recommendations was reached using the GRADE grid method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The working group summarized current available evidence of salt substitution regarding its effectiveness, safety, cost\u2010effectiveness, acceptability, availability, suitability, etc. The Guidelines provided six recommendations advising different populations how to use low sodium salt, four recommendations on the application of low sodium salts in different scenarios, and five suggestions for key stakeholders to promote salt substitution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The first evidence\u2010based guidelines on promotion and use of low sodium salts covers all key questions in relevance and would play a critical role in prevention and control of hypertension and cardiovascular disease in China and worldwide.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12621","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:05:28Z","timestamp":1719223528000},"page":"454-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Guidelines for use and promotion of low sodium salt in China"],"prefix":"10.1111","volume":"17","author":[{"given":"Yifang","family":"Yuan","sequence":"first","affiliation":[{"name":"Clinical Research Institute, Institute of Advanced Clinical Medicine Peking University  Beijing China"},{"name":"State Key Laboratory of Vascular Homeostasis and Remodeling Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[{"name":"National Institute for Nutrition and Health Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Population Medicine and Public Health Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, Institute of Advanced Clinical Medicine Peking University  Beijing China"},{"name":"Department of Preventive Medicine Shihezi University School of Medicine  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Ji","sequence":"additional","affiliation":[{"name":"Hypertension Center, National Center for Cardiovascular Diseases Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Fuwai Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Institute of Nephrology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Evidence\u2010Based Medicine Center, School of Basic Medical Sciences Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, Institute of Advanced Clinical Medicine Peking University  Beijing China"},{"name":"State Key Laboratory of Vascular Homeostasis and Remodeling Peking University  Beijing China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Report on Cardiovascular Health and Diseases in China 2022","author":"The Writing Committee of the Report on Cardiovascular Health and Diseases in China","year":"2023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14240"},{"issue":"10","key":"e_1_2_8_4_1","first-page":"1780","article-title":"Prevalence and control of hypertension in adults in China, 2018","volume":"42","author":"Zhang M","year":"2021","journal-title":"Chin J Epidemiol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.627741"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00829-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.257"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy121"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311889"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311989"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30041-8"},{"issue":"1","key":"e_1_2_8_12_1","first-page":"109","article-title":"Reducing salt intake in populations: report of a WHO forum and technical meeting","volume":"36","author":"World Health Organization","year":"2007","journal-title":"World Health Organization"},{"key":"e_1_2_8_13_1","volume-title":"Guideline: Sodium Intake for Adults and Children","author":"WHO Guidelines Approved by the Guidelines Review Committee","year":"2012"},{"key":"e_1_2_8_14_1","volume-title":"Guideline: Potassium Intake for Adults and Children","author":"WHO Guidelines Approved by the Guidelines Review Committee","year":"2012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2023.09.005"},{"issue":"32","key":"e_1_2_8_16_1","first-page":"5","article-title":"The Central Committee of the CPC and the State Council Print and Issue the Outline of the \u201cHealthy China 2030\u201d Plan","volume":"1571","year":"2016","journal-title":"The Gazette of the State Council of the People's Republic of China"},{"key":"e_1_2_8_17_1","unstructured":"World Health Organization.WHO Global Report on Sodium Intake Reduction 2023\u201003\u201009 [cited 2023\u201003\u201021 2023\u201003\u201021]. 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