{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T18:10:09Z","timestamp":1738433409830,"version":"3.35.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504701"],"award-info":[{"award-number":["2022YFC2504701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Narrowband ultraviolet B (NB\u2010UVB) has been recommended as first\u2010line therapy for early\u2010stage mycosis fungoides (MF) in international guidelines. NB\u2010UVB can be used as monotherapy or part of a multimodality treatment regimen. There is limited evidence on the effectiveness and optimal patients of NB\u2010UVB in combination with systemic therapies in MF. We aimed to assess the effectiveness of the combination versus NB\u2010UVB monotherapy in early\u2010stage MF and if plaque lesion status was related to these effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational cohort study included 247 early\u2010stage MF patients who had received NB\u2010UVB combined with systemic therapies vs. NB\u2010UVB monotherapy from 2009 to 2021. The primary outcome was partial or complete response. Overall response rate and median time to response were calculated. Hazard ratios (HRs) were estimated using the Cox model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 139 plaque\u2010stage patients, the response rate for combination therapy group was higher than that of monotherapy group (79.0%\u00a0vs. 54.3%, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.006). The adjusted HR for combination therapy compared with NB\u2010UVB monotherapy was 3.11 (95% CI 1.72\u20135.63). The combination therapy group also showed shorter time to response (4\u00a0vs. 6 months, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.002). In 108 patch\u2010stage patients, the response rate and time to response in two treatment groups showed no significant difference. There was therefore an observed interaction with patients\u2019 plaque lesion status for the effect size of NB\u2010UVB combination therapy. No serious adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adding systemic treatments to NB\u2010UVB did not improve the treatment outcome of patch\u2010stage patients, but it surpassed NB\u2010UVB monotherapy for early\u2010stage patients with plaques.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12623","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T06:23:59Z","timestamp":1718864639000},"page":"390-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of narrowband ultraviolet B monotherapy versus combination therapy with systemic agents in patients with early\u2010stage mycosis fungoides and the association with plaque lesions"],"prefix":"10.1111","volume":"17","author":[{"given":"Yao","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Peking University 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