{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:51:26Z","timestamp":1791445886381,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>While Baduanjin, a traditional Chinese mind\u2010body exercise, has shown potential health benefits, its efficacy in improving outcomes for heart failure patients with mildly reduced or preserved ejection fraction (HFmrEF\/HFpEF) has not been well documented. We aimed to investigate the adjunctive impact of Baduanjin on exercise capacity and quality of life for HFmrEF\/HFpEF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with HFmrEF\/HFpEF were enrolled in this multicenter randomized clinical trial. All participants were randomized to conventional cardiac rehabilitation with or without an additional 12\u2010week Baduanjin exercise. The primary endpoint was the distance covered in a 6\u2010min walk test (6MWD), while key secondary outcomes included quality of life measured by the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and cardiopulmonary function including anaerobic threshold (VO<jats:sub>2<\/jats:sub> AT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 120 patients were enrolled, and 109 completed all session and tests. The mean age of the 120 patients was 60.5 years (SD, 9.21 years), and 23 (19.2%) were women. The Baduanjin group exhibited a 6.14% improvement in 6MWD compared to a 1.32% improvement in the control group (median improvement, 25.0\u00a0vs. 5.0\u00a0m; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) at 12th week. The VO<jats:sub>2<\/jats:sub> AT increased by 25.87% in the Baduanjin group versus 3.94% in the control group (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). Quality of life also significantly improved in the Baduanjin group as indicated by MLHFQ score changes (\u201316.8% vs. \u20133.99%; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adding Baduanjin to exercise\u2010based cardiac rehabilitation for patients with ischemic HFmrEF or HFpEF are generally safe and could provide significant improvements in exercise capacity and quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.12631","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T07:13:10Z","timestamp":1720249990000},"page":"526-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Baduanjin for ischemic heart failure with mildly reduced\/preserved ejection fraction (BEAR Trial): A randomized controlled trial"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-950X","authenticated-orcid":false,"given":"Jingen","family":"Li","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing China"},{"name":"Department of Cardiovascular Medicine Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing China"},{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Beijing First Hospital of Integrated Traditional Chinese and Western Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Beijing First Hospital of Integrated Traditional Chinese and Western Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Beijing Hepingli Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Feng","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Center Fuwai Hospital of Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Beijing First Hospital of Integrated Traditional Chinese and Western Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keji","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 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