{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:31:39Z","timestamp":1791095499088,"version":"4.1.0"},"reference-count":96,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305308"],"award-info":[{"award-number":["82305308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Tic disorders are neurodevelopmental conditions that manifest in childhood or adolescence and can significantly impact the quality of life of affected children and their families to varying degrees. Integrated traditional Chinese and Western medicine treatment strategies have demonstrated more pronounced efficacy and better safety profiles. However, there is currently no standardized clinical expert consensus on this approach. To address this, the National Administration of Traditional Chinese Medicine initiated a project, and the China Association of Chinese Medicine assembled a team of authoritative domestic experts to develop this expert consensus, aiming to provide practical and feasible integrated treatment strategies for clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This consensus identified clinical issues through research, conducted literature reviews, and established evidence based on systematic evaluations. Expert surveys, two rounds of Delphi questionnaires, and expert consensus meetings were conducted to formulate a series of recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We established a multidisciplinary consensus development panel. Based on systematic literature reviews, Delphi questionnaires, and consensus meetings, ten clinical issues were identified. Ultimately, a series of recommendations were developed, considering the balance of benefits and risks, the certainty of evidence, clinical feasibility, accessibility, and clinical acceptability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These recommendations comprehensively address key issues in the field of integrated traditional Chinese and Western medicine treatment, including indications for the use of Chinese or Western medicine alone or in combination, specific treatment protocols, methods for dose reduction and discontinuation, evaluation intervals, and the management of adverse reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jebm.70012","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:22:01Z","timestamp":1748337721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chinese Expert Consensus on Integrated Chinese and Western Medicine for the Treatment of Tic Disorders"],"prefix":"10.1111","volume":"18","author":[{"given":"Rong","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pediatrics First Teaching Hospital of Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dongfang Hospital Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Psychiatry, Beijing Anding Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Hospital Management Office Zhejiang University of Chinese Medical  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Behavioral Development Guangzhou Women and Children's Medical Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Third Affiliated Hospital of Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Beijing Children's Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhao","family":"Guo","sequence":"additional","affiliation":[{"name":"Ten Departments of Encephalopathy Xi 'an Encephalopathy Hospital of Traditional Chinese Medicine  Xi'an 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Chaohu Hospital of Anhui Medical University  Chaohu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Peking University Sixth Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhisheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Wuhan Maternal and Child Health Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuerong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Children's Brain Disease Diagnosis and Rehabilitation Center The First Affiliated Hospital of Henan University of TCM  Zhengzhou 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