{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:49:28Z","timestamp":1782301768717,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270384"],"award-info":[{"award-number":["82270384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of intravenous iron therapy in heart failure (HF) patients with iron deficiency (ID) is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We performed an extensive search of electronic databases for pertinent studies, encompassing all records up to March 4, 2024. Using random\u2010effects models in a meta\u2010analysis, the collected outcomes data were then synthesized and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Fourteen trials with 7786 participants (iron therapy:\n                      <jats:italic>n<\/jats:italic>\n                      = 3994; control:\n                      <jats:italic>n<\/jats:italic>\n                      = 3792) were included. Intravenous iron therapy can decrease the risk of composite events of total hospitalization for HF and cardiovascular (CV) death (RR = 0.82 [0.72, 0.92]), total hospitalization for HF (RR = 0.78 [0.66, 0.91]), first hospitalization for HF and CV death (OR = 0.78 [0.65, 0.93]), CV death (OR = 0.86 [0.76, 0.98]), first hospitalization for HF(OR = 0.77 [0.61, 0.99]), but not significantly reduce the risk of all\u2010cause mortality (OR = 0.93 [0.83, 1.04]). Furthermore, intravenous iron treatment can improve the distance of 6\u2010min walking test (6MWT) (WMD = 18.99 [7.41, 30.57]). Subgroup analyses found that intravenous iron may be more beneficial in HF patients with transferrin saturation (TSAT) &lt;20%, and those with ischemic heart disease. Meta\u2010regression analysis revealed that baseline hemoglobin levels served as a significant moderator of the therapeutic efficacy of intravenous iron supplementation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For HF patients with ID, intravenous iron therapy can decrease the risk of hospitalization for HF, CV death and improve their exercise capacity. Patients with ischemic cardiomyopathy or with TSAT &lt;20% may derive greater benefit from intravenous iron therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70057","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T14:14:58Z","timestamp":1755180898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intravenous Iron in Heart Failure Patients With Iron Deficiency: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"18","author":[{"given":"Yangguang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People\u2019s Hospital of Shunde, Foshan) Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People\u2019s Hospital of Shunde, Foshan) Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People\u2019s Hospital of Shunde, Foshan) Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People\u2019s Hospital of Shunde, Foshan) Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People\u2019s Hospital of Shunde, Foshan) Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology the Lecong Hospital of Shunde Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5423-5487","authenticated-orcid":false,"given":"Yuli","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People\u2019s Hospital of Shunde, Foshan) Foshan China"},{"name":"Faculty of Medicine The George Institute For Global Health University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.026"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2017.1351239"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.01.017"},{"issue":"6","key":"e_1_2_6_6_1","first-page":"523","article-title":"2021 ESC Guidelines for the diagnosis and treatment of Acute and Chronic Heart Failure: Developed by the Task Force for the diagnosis and Treatment of Acute and Chronic Heart Failure of the European Society of Cardiology (ESC) with the Special Contribution of the Heart Failure Association (HFA) of the ESC","volume":"75","author":"McDonagh T. A.","year":"2022","journal-title":"Revista Espanola De Cardiologia (English Ed)"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.04.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.12.011"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.823"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02083-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304968"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.3833"},{"key":"e_1_2_6_13_1","unstructured":"J. P. T.HigginsandS.Green(eds).Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration (2011) handbook.cochrane.org."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12507"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.029"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.036"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908355"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu385"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027497"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12250"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038516"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014254"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32339-4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2144\/fsoa-2019-0156"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab411"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad586"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2308305"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.103366"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-815944"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13004"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024014283"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.0452"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004519"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.04.110"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.040845"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.15227"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2810"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.030099"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00951-6"}],"container-title":["Journal of Evidence-Based Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.70057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jebm.70057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.70057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:28:36Z","timestamp":1776223716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jebm.70057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/jebm.70057"],"URL":"https:\/\/doi.org\/10.1111\/jebm.70057","archive":["Portico"],"relation":{},"ISSN":["1756-5383","1756-5391"],"issn-type":[{"value":"1756-5383","type":"print"},{"value":"1756-5391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]},"assertion":[{"value":"2025-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70057"}}