{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:37:29Z","timestamp":1787168249038,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172543"],"award-info":[{"award-number":["82172543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH071"],"award-info":[{"award-number":["ZR2024MH071"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate and compare the effectiveness of adherence\u2010enhancement strategies in patients with chronic kidney disease (CKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine databases (PubMed, Embase, The Cochrane Library, Web of Science, Scopus, CNKI, VIP, WanFang, and CBM) were searched for randomized controlled trials (RCTs) to April 1, 2025. Two reviewers independently screened, extracted data, and assessed risk of bias with the Cochrane Risk of Bias 2.0 tool. Certainty of evidence was appraised using the Confidence in Network Meta\u2010Analysis (CINeMA) tool. Network meta\u2010analysis was performed, and surface under the cumulative ranking curve (SUCRA) was calculated to rank interventions. The review was registered in PROSPERO (CRD42024604771).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010five RCTs with 5084 patients were included. Evidence quality was limited by high risk of bias and low certainty. For medication adherence, education plus phone follow\u2010up with short message service education showed the greatest effect (standardized mean differences [SMD] = 2.15, 95% confidence interval [CI] 1.09\u20133.21; SUCRA = 98.7), followed by empowerment (SMD = 1.19, 95% CI 0.20\u20132.18; SUCRA = 82.1). For diet adherence, education with phone follow\u2010up was most effective (SMD = 6.68, 95% CI 5.64\u20137.71; SUCRA = 100), with empowerment also beneficial (SMD = 1.83, 95% CI 1.23\u20132.43; SUCRA = 87.9). For fluid adherence, education with medication management and pharmacist follow\u2010up was most effective on scale\u2010based outcomes (SMD = 3.06, 95% CI 2.18\u20133.94; SUCRA = 99.8), while cognitive behavioral therapy reduced interdialytic weight gain (SMD = \u22120.76, 95% CI \u22121.30 to \u22120.22; SUCRA = 71.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adherence\u2010enhancement strategies improve medication, diet, and fluid adherence in CKD. High\u2010quality RCTs are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70078","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T06:16:00Z","timestamp":1758780960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Systematic Review and Network Meta\u2010Analysis of the Comparative Effectiveness of Adherence Enhancement Strategies in Chronic Kidney Disease"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-4581","authenticated-orcid":false,"given":"Bin","family":"Ma","sequence":"first","affiliation":[{"name":"School of Nursing and Rehabilitation Cheeloo College of Medicine,Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanmin","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Nursing and Rehabilitation 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