{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T21:40:12Z","timestamp":1769982012035,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3502300"],"award-info":[{"award-number":["2022YFC3502300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3502304"],"award-info":[{"award-number":["2022YFC3502304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data from Hospital Information Systems are crucial components of real\u2010world data, but concerns arise regarding the transparency of measurement time\u2010points when directly utilizing for efficacy studies. The objective of the study was to analyze the distribution characteristics of time\u2010points for laboratory test records from HIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Medical records before December 31, 2019 from Affiliated Hospital of Shandong University of Traditional Chinese Medicine, for patients primarily diagnosed with coronary heart disease (CHD), or heart failure combined with secondary diagnosis of CHD were retrieved from HIS. Fifteen test groups were extracted. The number of records, average of test times, and distribution characteristics of time points were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The renal function tests have the most records, and the blood glucose have the most times. Tests time\u2010points distribution showed concentration in the early stage of hospitalization, with the majority occurring within the first 0\u201310%. For those measured \u22652 times, their first tests are also centrally distributed in the early stage, while the lasts in all period of hospitalization. Besides, substantial difference is showed in the time span of the first and last test. Abnormal value may be a trigger that promotes more intensive examination, and normal or abnormal status of the first examination is significantly weak to moderate correlated with the number of examinations and time span.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The disclosure of time\u2010points of clinical studies based on HIS should be encouraged and the pre\u2010survey of data measuring time point is essential to the design of trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70079","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T03:19:36Z","timestamp":1760584776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can Real\u2010World Data From Hospital Information Systems Be Directly Utilized for Efficacy Studies: An Analysis of Data Time Points"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2426-7035","authenticated-orcid":false,"given":"Jiaying","family":"Luo","sequence":"first","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aomeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wulin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangwei","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Guang'anmen Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehui","family":"Ye","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6570-8739","authenticated-orcid":false,"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Affiliated Hospital 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