{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:08Z","timestamp":1787015528947,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop an evidence\u2010based patient version of guideline (PVG) for fibromyalgia, aiming to improve patients\u2019 understanding of disease symptoms and therapeutic options and to enhance their self\u2010management abilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following the World Health Organization Handbook for Guideline Development (2014), a multidisciplinary working group was established, including patient representatives, physicians, pharmacists, nurses, and methodologists. The process comprised (a) systematic retrieval of clinical practice guidelines and expert consensus statements to establish the evidence base; (b) integration of large language models (LLMs) with expert review to identify and refine key patient\u2010centered concerns; (c) a three\u2010round Delphi consensus guided by the Grading of Recommendations Assessment, Development and Evaluation approach to finalize clinical questions and formulate recommendations; and (d) evaluation of understandability using the Patient Education Materials Assessment Tool for Print Materials (PEMAT\u2010P).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The final PVG covers 13 clinical questions across seven domains, including disease awareness, diagnostic evaluation, pharmacological and non\u2010pharmacological interventions, and long\u2010term management. All recommendations were rated as strong. The guideline emphasizes the importance of pharmacological management, emotional regulation, and exercise in the comprehensive management of fibromyalgia. The PEMAT\u2010P assessment showed an understandability score of 100%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Developed collaboratively by a multidisciplinary team and patient representatives, this PVG is based on 13 evidence\u2010based fibromyalgia guidelines. Combining LLMs with expert review enhanced question generation and readability. The PVG provides a practical and accessible tool to support early self\u2010management in fibromyalgia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70094","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:16:19Z","timestamp":1766056579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patient Version of Guideline for Fibromyalgia (2025 Edition)"],"prefix":"10.1111","volume":"18","author":[{"given":"Zhiling","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Department of Pharmacy Beijing Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengxiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing 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Anzhen Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qipeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Mai","sequence":"additional","affiliation":[{"name":"Patient Representative for Fibromyalgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghui","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Patient Representative for Fibromyalgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangjun","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of 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