{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:02:19Z","timestamp":1789488139306,"version":"build-2803163510"},"reference-count":81,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200189"],"award-info":[{"award-number":["82200189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070217"],"award-info":[{"award-number":["82070217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873446"],"award-info":[{"award-number":["81873446"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873427"],"award-info":[{"award-number":["81873427"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Cytomegalovirus (CMV) is an increasingly recognized complication of chimeric antigen receptor T\u2010cell (CAR\u2010T) and bispecific antibody (BsAb) therapies for hematologic malignancies, driven by therapy\u2010related immunosuppression and cumulative exposure to lymphodepleting or steroid regimens. Given China's high adult CMV IgG seroprevalence (&gt;90%), baseline risk, interpretation of low\u2010level DNAemia, and operational thresholds differ from low\u2010seroprevalence settings, requiring context\u2010specific guidance. This China\u2010adapted, evidence\u2010graded consensus was developed by a multidisciplinary panel from major centers using a modified Delphi process and Oxford Centre for Evidence\u2010Based Medicine levels to translate international guidance into a high\u2010seroprevalence setting. Recommendations prioritize early risk stratification and pragmatic surveillance. We advise routine CMV monitoring by real\u2010time quantitative PCR during the first 30 days after therapy, with risk\u2010adapted extension thereafter. Interpretation and treatment triggers are anchored to WHO\u2010traceable IU\/mL and specified by specimen matrix to support comparability across assays. Consideration of prophylaxis is proposed for well\u2010defined high\u2010risk subgroups, acknowledging the need for prospective validation. Syndrome\u2010based diagnostic and treatment algorithms are provided for tissue\u2010invasive disease, including CMV pneumonia and encephalitis, with guidance on antiviral induction, step\u2010down, and monitoring for virologic response and drug toxicity. This consensus explicitly adapts international recommendations to China's epidemiology, assay practice, and drug accessibility. By standardizing prevention, surveillance, and management in CAR T\u2010cell and BsAb recipients, this consensus aims to lower non\u2010relapse mortality and improve long\u2010term outcomes. Priority research needs include harmonized viral\u2010load thresholds, validation of risk\u2010adapted prophylaxis strategies, and studies that clarify the significance of low\u2010level DNAemia in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70107","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:47:10Z","timestamp":1768380430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Expert Consensus on Cytomegalovirus Management in Recipients of CAR\u2010T Cell and Bispecific Antibody Therapies"],"prefix":"10.1111","volume":"19","author":[{"given":"Wenyue","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Hematology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fankai","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhou","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin First Central Hospital, The First Affiliated Central Hospital of Nankai University, The First Central Clinical College of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Sun","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease Peking University People's Hospital &amp; Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hematology Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxian","family":"Hu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center The First Affiliated Hospital, School of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army General Hospital of Western Theater Command  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of SooChow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation Chinese Academy of Medical Sciences  Wuhan Hubei China"},{"name":"Immunotherapy Research Center for Hematologic Diseases of Hubei Province  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Immunotherapy Research Center for Hematologic Diseases of Hubei Province  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.05.039"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01035-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7372"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27198"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13712"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad708"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00879-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100810"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00159-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004000"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000001066"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024012922"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03084-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27071"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27257"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024015164"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(25)00069-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2025.06.025"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy696"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12260"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-23-0049"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00563-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29020044"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-022-00721-y"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2313812"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.09.007"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1226148"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01139-y"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02197"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010539"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009435"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15496"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000388"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.07.018"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022432"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ215"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0790-z"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184671"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-694356"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2021.1855143"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01043-5"},{"issue":"25","key":"e_1_2_7_44_1","first-page":"04264","article-title":"Preemptive Immunoglobulin Prophylaxis Reduces Infections in Patients Treated With Anti\u2010BCMA Bispecific Antibodies","author":"Piron B.","year":"2025","journal-title":"Clinical Lymphoma Myeloma and Leukemia"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181cee42f"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000005374"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx143"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2016.04.005"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000936"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2023.02.008"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1210"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis818"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix192"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00385-08"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24989"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.655"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1086\/508173"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00203-06"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40506-021-00253-w"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00344-7"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.9106"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.03.028"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.01.027"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab466.1125"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad709"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13584"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16450"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae321"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00009-10"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab988"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.02.029"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae422"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636897231194265"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.11.013"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2025016490"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1459"},{"issue":"6","key":"e_1_2_7_78_1","first-page":"556","article-title":"[Cytomegalovirus Pneumonia After Allogeneic Hematopoietic Stem Cell Transplantation]","volume":"60","author":"Li S.","year":"2021","journal-title":"Zhonghua Nei Ke Za Zhi [Chinese Journal of Internal Medicine]"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13443"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2019.1710945"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000541"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2023.105792"}],"container-title":["Journal of Evidence-Based Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.70107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jebm.70107","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.70107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:04:09Z","timestamp":1789484649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jebm.70107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":81,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jebm.70107"],"URL":"https:\/\/doi.org\/10.1111\/jebm.70107","archive":["Portico"],"relation":{},"ISSN":["1756-5383","1756-5391"],"issn-type":[{"value":"1756-5383","type":"print"},{"value":"1756-5391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"2025-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70107"}}