{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:02:22Z","timestamp":1789488142175,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence regarding the impact of age at hypertension onset on brain atrophy, independent of hypertension duration, remains limited. This study investigated whether the association between hypertension and brain volume differs by age at hypertension diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a multicenter, community\u2010based cohort study (initiated in 2006), 948 participants were included: 117 early\u2010onset hypertensives (diagnosed \u226440 years), 354 late\u2010onset hypertensives (diagnosed &gt;40 years), and 477 non\u2010hypertensive controls, matched through propensity score matching. Neuroimaging data have been collected since 2020 to assess brain volume. The associations between early\u2010onset and late\u2010onset hypertension with brain volume were evaluated using the voxel\u2010wise and generalized linear models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to controls, early\u2010onset hypertension was associated with lower volumes of cerebral parenchyma (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.302; 95% confidence interval [CI], \u22120.541 to \u22120.063) and gray matter (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.338; 95% CI, \u22120.590 to \u22120.087). The frontal, occipital, and temporal lobes showed the most prominent volume loss. Compared to participants with late\u2010onset hypertension, early\u2010onset hypertensives exhibited more pronounced brain volume reductions, especially in the frontal lobe. In contrast, compared with the matched non\u2010hypertensive controls, the pattern of brain volume reduction in the late\u2010onset hypertension group was similar to that in the early\u2010onset hypertension group at the voxel level but did not reach statistical significance after full adjustment for covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is a significant correlation between early\u2010onset hypertension and brain atrophy. It is crucial to manage blood pressure at a young age. For patients diagnosed with hypertension before the age of 40, it is recommended to strengthen brain health monitoring while undergoing antihypertensive treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70127","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T06:27:42Z","timestamp":1774247262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Age at Hypertension Diagnosis and Brain Health: A Population\u2010Based Cohort Study"],"prefix":"10.1111","volume":"19","author":[{"given":"Xiaoqing","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Radiology Capital Medical University Affiliated Beijing Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Technology School of Medical Technology, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiology Capital Medical University Affiliated Beijing Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for MRI Research Academy for Advanced Interdisciplinary Studies Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Radiology Kailuan General Hospital  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology Capital Medical University Affiliated Beijing Friendship Hospital  Beijing 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