{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:28:43Z","timestamp":1783024123214,"version":"3.54.6"},"reference-count":91,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to provide a comprehensive overview of the cost\u2010effectiveness of COVID\u201019 vaccination strategies and examine the reporting quality of the included studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was performed across PubMed, Web of Science, Embase, Cochrane Library, the International Network of Agencies for Health Technology Assessment, and Chinese databases (CNKI, WanFang, VIP, and SinoMed). Health economic evaluations published from inception to December 19, 2024, considering both costs and effects of vaccination strategies for COVID\u201019 were included. The reporting quality of the included studies was comprehensively assessed according to the Consolidated Health Economic Evaluation Reporting Standards Checklist (CHEERS) 2022. A narrative synthesis was employed to summarize and present the findings across diverse vaccination strategies. To ensure transparency, the study protocol was registered prospectively in the Prospective Register of Systematic Reviews (CRD42025629706).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 68 studies were included. These studies were heterogeneous concerning reporting quality, vaccination strategies, adopted perspective, applied models, and outcome indicator used. The CHEERS quality scoring rate of 68 studies ranged from 23% to 88%, with a median of 71%. Vaccination was consistently found more cost\u2010effective or cost\u2010saving than no vaccination. Prioritizing high\u2010risk populations, particularly older adults, delivered even higher economic benefits across diverse settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>COVID\u201019 vaccination remains cost\u2010effective globally. While rapid deployment and high risk prioritization maximize economic benefits, optimal strategies are sensitive to epidemiological and methodological factors, placing substantial demands on policymakers. Future research should integrate long\u2010term impacts, health equity, and reporting standards to strengthen evidence based vaccination policies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70136","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:22:52Z","timestamp":1782883372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2010Effectiveness of Vaccination Strategies for COVID\u201019: A Systematic Review"],"prefix":"10.1111","volume":"19","author":[{"given":"Yi","family":"Yang","sequence":"first","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"},{"name":"National Health Commission Key Laboratory of Health Technology Assessment Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Weng","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"},{"name":"National Health Commission Key Laboratory of Health Technology Assessment Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tao","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"},{"name":"National Health Commission Key Laboratory of Health Technology Assessment Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxing","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"},{"name":"National Health Commission Key Laboratory of Health Technology Assessment Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Lian","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"},{"name":"National Health Commission Key Laboratory of Health Technology Assessment Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuming","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"},{"name":"National Health Commission Key Laboratory of Health Technology Assessment Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"},{"name":"National Health Commission Key Laboratory of Health Technology Assessment Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"},{"name":"National Health Commission Key Laboratory of Health Technology Assessment Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization \u201cWHO COVID\u201019 Dashboard\u201d [cited 2025 05\u201030].https:\/\/data.who.int\/dashboards\/covid19\/."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-024-02476-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100863"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2196\/27419"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15091786"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines13060638"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00320-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-022-00177-6"},{"key":"e_1_2_6_10_1","unstructured":"\u201c\u2018Unprecedented Achievement\u2019: Who Received the First Billion COVID Vaccinations? 2021\u201d [cited 2025 04\u201011].https:\/\/www.nature.com\/articles\/d41586\u2010021\u201001136\u20102."},{"key":"e_1_2_6_11_1","unstructured":"\u201cOnly 58 Countries Meet WHO's 70% COVID Vaccination Target: WHO Chief\u201d [cited 2025 06\u201002].https:\/\/www.thehindubusinessline.com\/news\/national\/only\u201058\u2010countries\u2010meet\u2010whos\u201070\u2010per\u2010cent\u2010covid\u2010vaccination\u2010target\u2010who\u2010chief\/article65612502.ece."},{"key":"e_1_2_6_12_1","unstructured":"\u201cWorld Health Organization. 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