{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:28:31Z","timestamp":1783024111605,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy and safety of OsteoKing compared to a standard active comparator (Yaobitong capsules) for managing lumbar disc herniation (LDH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A randomized, double\u2010blind, double\u2010dummy, positive\u2010controlled, multicenter trial was conducted across 17 hospitals in China. A total of 210 eligible patients with LDH were randomized in a 2:1 ratio to receive either OsteoKing (\n                      <jats:italic>n<\/jats:italic>\n                      = 140) or Yaobitong capsules (\n                      <jats:italic>n<\/jats:italic>\n                      = 70) for 4 weeks. The primary efficacy endpoint was the change in the Visual Analog Scale (VAS) score from baseline to week 4. Secondary endpoints included the Oswestry Disability Index score, the resolution rate of individual traditional Chinese medicine symptoms, and safety assessments. Missing data and repeated measures were handled using multiple imputation and a mixed\u2010model for repeated measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics were well\u2010matched between the two groups. At week 4, both groups experienced substantial improvements in pain and lumbar function. In the full analysis set (FAS), the between\u2010group least squares mean difference (LSMD) in VAS reduction was \u22120.37 (95% CI: \u22120.77 to 0.03;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.074). In the per\u2010protocol set (PPS) analysis, the OsteoKing group achieved a significantly greater reduction in VAS scores compared to the control group (LSMD: \u22120.41, 95% CI: \u22120.82 to \u22120.01;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0453). Improvements in ODI scores were comparable between the groups in both the FAS and PPS analyses (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). Additionally, the OsteoKing group demonstrated significantly higher resolution rates for low back pain and fatigue\/lassitude at week 4 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Both treatments were safe and well\u2010tolerated, with comparable incidence rates of adverse events (21.43%\u00a0vs. 24.29%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.6396).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OsteoKing demonstrated comparable overall efficacy and safety to Yaobitong capsules in improving lumbar function and relieving symptoms in patients with LDH. Furthermore, OsteoKing may offer a modest, short\u2010term analgesic advantage at the 4\u2010week mark. OsteoKing represents a safe, effective, and viable conservative therapeutic option for LDH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70140","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:48:08Z","timestamp":1782398888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of OsteoKing in the Treatment of Lumbar Disc Herniation: A Randomized, Double\u2011Blind, Double\u2011Dummy, Positive\u2011Controlled, Multicenter Clinical Trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Zhuoyun","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China"},{"name":"Engineering Research Center of Chinese Orthopaedics and Sports Rehabilitation Artificial Intelligence Ministry of Education  Bejing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Joint Surgery Third Affiliated Hospital of Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China"},{"name":"Department of Massage Shanxi Provincial Hospital of Traditional Chinese Medicine  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuayue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China"},{"name":"Engineering Research Center of Chinese Orthopaedics and Sports Rehabilitation Artificial Intelligence Ministry of Education  Bejing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China"},{"name":"Engineering Research Center of Chinese Orthopaedics and Sports Rehabilitation Artificial Intelligence Ministry of Education  Bejing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Heilongjiang Provincial Hospital of Traditional Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangqing","family":"Du","sequence":"additional","affiliation":[{"name":"Third Department of Orthopedics and Traumatology Hebei Provincial Hospital of Traditional Chinese Medicine  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics People's Hospital of Banan District  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics TISCO General Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Fenyang Hospital of Shanxi Province  Lvliang 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Hospital of Traditional Chinese Medicine  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sixth Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics General Hospital of Xuzhou Mining Group  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics General Hospital of Anshan Iron and Steel Group Corporation  Anshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Meishan Hospital of Traditional Chinese Medicine  Meishan 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Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China"},{"name":"Engineering Research Center of Chinese Orthopaedics and Sports Rehabilitation Artificial Intelligence Ministry of Education  Bejing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wnsx.2024.100279"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00769-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.08.003"},{"key":"e_1_2_7_5_1","first-page":"132","article-title":"Chinese Association of Rehabilitation Medicine Spine and Spinal Cord Professional Committee Lumbar Spine Research Group. 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