{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:59:14Z","timestamp":1790330354628,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302632"],"award-info":[{"award-number":["82302632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC0550"],"award-info":[{"award-number":["2025ZNSFSC0550"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess associations of the triglyceride\u2010glucose (TyG) index and cholesterol high\u2010density lipoprotein glucose (CHG) index with overall survival (OS) and progression\u2010free survival (PFS) in gastric cancer (GC), and to explore whether prognostic value differs by pathological stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using routinely collected electronic medical record data from West China Hospital, Sichuan University, including patients who underwent GC resection between 2008 and 2021. TyG and CHG were calculated from preoperative laboratory parameters. Associations with OS and PFS were assessed using multivariable Cox models, with subgroup analyses by pathological stage. Kaplan\u2013Meier and time\u2010dependent receiver operating characteristic analyses were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the overall cohort, TyG and CHG have no independent association with OS or PFS after adjustment. Subgroup analyses stratified by cancer stage showed higher CHG index was associated with worse OS in Stage 1 (hazard ratios [HR] = 2.038, 95% confidence interval [CI]: 1.336\u20133.110,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), whereas higher TyG index was associated with better OS in Stage 4 (HR = 0.860, 95% CI: 0.756\u20130.980,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.023). Kaplan\u2013Meier analyses supported these stage\u2010specific associations. CHG showed the best predictive performance for Stage 1 OS, while TyG index showed relatively stable discrimination for Stage 4 OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prognostic value of TyG and CHG in GC appears to be stage\u2010dependent. CHG index may be more useful in stage 1, whereas lower TyG index may indicate poorer prognosis in stage 4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70142","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:19:33Z","timestamp":1782922773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of the TyG Index and CHG Index in Gastric Cancer"],"prefix":"10.1111","volume":"19","author":[{"given":"Yazhi","family":"Mo","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital, Sichuan University Sichuan Clinical Research Center for Laboratory Medicine, Clinical Laboratory Medicine Research Center of West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital, Sichuan University Sichuan Clinical Research Center for Laboratory Medicine, Clinical Laboratory Medicine Research Center of West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital, Sichuan University Sichuan Clinical Research Center for Laboratory Medicine, Clinical Laboratory Medicine Research Center of West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital, Sichuan University Sichuan Clinical Research Center for Laboratory Medicine, Clinical Laboratory Medicine Research Center of West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanying","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital, Sichuan University Sichuan Clinical Research Center for Laboratory Medicine, Clinical Laboratory Medicine Research Center of West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital, Sichuan University Sichuan Clinical Research Center for Laboratory Medicine, Clinical Laboratory Medicine Research Center of West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonghao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Virginia  Charlottesville Virginia 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