{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:28:29Z","timestamp":1783024109949,"version":"3.54.6"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574861"],"award-info":[{"award-number":["82574861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of acupuncture for knee osteoarthritis across different comparators, including usual care, sham acupuncture, waiting\u2010list, pharmacological treatments, and other non\u2010pharmacological interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An umbrella review of systematic reviews\/meta\u2010analyses of acupuncture in adults with knee osteoarthritis was performed. MEDLINE, Embase, Cochrane Library, CNKI, WanFang, and VIP databases were searched. Comparisons were conducted among different acupuncture types. Methodological quality was assessed using Revised Assessment of Multiple Systematic Reviews (R\u2010AMSTAR), and the best available evidence was selected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010three systematic reviews were included, with a mean R\u2010AMSTAR score of 30.87. Most acupuncture modalities showed consistent improvements in pain and physical function. Compared with sham acupuncture, usual care, and waiting\u2010list, acupuncture produced clinically meaningful improvements in pain and joint function. Compared with pharmacological treatments, acupuncture demonstrated effects similar to non\u2010steroidal anti\u2010inflammatory drugs, while electroacupuncture was superior in improving joint stiffness and overall response rates. Compared with Tui Na or massage, acupuncture showed a slower onset of effect and similar or slightly inferior improvements in function and stiffness. Adverse events were generally mild and local, with a lower risk of gastrointestinal complications. Treatment effects were most evident at the end of treatment and during short\u2010term follow\u2010up (&lt;3 months), whereas long\u2010term evidence remained limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acupuncture of all modalities relieves pain and improve function in knee osteoarthritis patients, thus is a key non\u2010pharmacological option or add\u2010on therapy when medications are unsuitable. For optimal and sustained effect of acupuncture treatment in knee osteoarthritis, more rigorous sham acupuncture\u2013controlled designs and long\u2010term follow\u2010up are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70143","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:28:14Z","timestamp":1782397694000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Effects of Acupuncture in the Treatment of Knee Osteoarthritis: An Umbrella Review of Level I Evidence"],"prefix":"10.1111","volume":"19","author":[{"given":"Yunxiao","family":"Yang","sequence":"first","affiliation":[{"name":"School of Medical and Life Sciences Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlin","family":"Long","sequence":"additional","affiliation":[{"name":"Innovation Institute for Integration of Medicine and Engineering West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine The Third People's Hospital of Chengdu  Chengdu 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