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We conducted a network meta\u2010analysis using random effects to compare the change of systolic\/diastolic blood pressure (SBP\/DBP) between the following interventions: second\u2010generation renal denervation (RDN), mineralocorticoid receptor antagonist (MRA), endothelin receptor antagonist, aldosterone synthase inhibitor (ASI), sodium\u2010glucose cotransporter\u20102 inhibitors, baroreflex activation therapy, central arteriovenous anastomosis, lifestyle, and control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010three eligible studies were included in the final analysis. After conducting sensitivity analyses, MRA significantly lowered both office and 24\u2010h blood pressure (BP) compared to control group (mean difference \u20139.11, [95% confidence interval \u201310.44 to \u20137.79] for office SBP; \u20134.97 [\u20135.83 to \u20134.11] for office DBP; \u20139.64 [\u201311.73 to \u20137.54] for 24\u2010h SBP; \u20133.75 [\u20135.08 to \u20132.42] for 24\u2010h DBP). RDN effectively reduced both office and 24\u2010h BP, and it caused a large reduction in office DBP compared to control group (\u20136.63 [\u20138.58 to \u20134.68] for office DBP; \u20133.36 [\u20134.57 to \u20132.14] for 24\u2010h DBP). Lifestyle and ASI effectively reduced office and 24\u2010h BP, and it as well as MRA were almost in the top three treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRA can be the priority treatment for RH. ASI and RDN are also optimal alternatives to MRA, particularly suitable for 24\u2010h BP and uncontrolled DBP management, respectively. A combination of lifestyle alongside pharmacological\/device\u2010based therapies may represent the optimal approach. More trials concerning other treatments for RH are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70154","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:49:43Z","timestamp":1783072183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the Efficacy of Different Treatment Regimens for Resistant Hypertension: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"19","author":[{"given":"Yao","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Cardiology West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs West China Hospital Sichuan University  Chengdu China"},{"name":"Chinese Evidence\u2010Based Medicine Center West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology West China Hospital Sichuan University  Chengdu 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