{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:59:23Z","timestamp":1790330363449,"version":"4.1.0"},"reference-count":299,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3605900\/02"],"award-info":[{"award-number":["2023YFC3605900\/02"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Older patients receiving end\u2010of\u2010life palliative care often present with multiple geriatric syndromes, frailty, and comorbid symptom burden, resulting in a high risk of medication\u2010related harm. This guideline focuses on pharmacological management of distressing symptoms in older patients receiving end\u2010of\u2010life or hospice\u2010oriented palliative care, rather than disease\u2010modifying treatment of chronic conditions. The guideline was developed in accordance with the standards of the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) system and the Reporting Items for Practice Guidelines in Healthcare (RIGHT). It addresses 15 common distressing symptoms and provides 65 recommendations. On the basis of the best available evidence, patient values, feasibility, and expert consensus, the panel formulated recommendations intended to support safe, rational, individualized, and goal\u2010concordant medication use in older patients at the end of life. This guideline aims to identify and recommend appropriate pharmacological treatments for common and refractory symptoms in older palliative care patients and to provide guidance for healthcare professionals on safe, rational, and standardized medication use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70160","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:23:41Z","timestamp":1783747421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Guideline for Medication Management of Distressing Symptoms in Older Patients Receiving End\u2010of\u2010Life Palliative Care"],"prefix":"10.1111","volume":"19","author":[{"given":"Daiping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Emergency, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirong","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"110","article-title":"Palliative Care: An Update","volume":"114","author":"Cruz\u2010Oliver D. M.","year":"2017","journal-title":"Missouri Medicine"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-025-06344-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/23337214231183243"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32080433"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201803060"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2024.105461"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19063195"},{"issue":"14","key":"e_1_2_7_9_1","first-page":"1717","article-title":"Chinese Guideline for Use of Essential Medicines in Palliative and Hospice Care","volume":"24","author":"General Practice Branch of Chinese Medical Association, Chinese Medical Doctor Association","year":"2021","journal-title":"Chinese General Practice"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ejhpharm-2020-002554"},{"issue":"3","key":"e_1_2_7_11_1","first-page":"487","article-title":"Potentially Inappropriate Medication in Older Adults With Palliative Care at Home","volume":"84","author":"Mozeluk N. B.","year":"2024","journal-title":"Medicina (B Aires)"},{"issue":"10","key":"e_1_2_7_12_1","first-page":"659","article-title":"Polypharmacy and Medication Errors on Admission to Palliative Care","volume":"129","author":"Gr\u0105dalski T.","year":"2019","journal-title":"Polish Archives of Internal Medicine"},{"issue":"12","key":"e_1_2_7_13_1","first-page":"1384","article-title":"Protocol for Medication Guideline for Symptom Management in Elderly Hospice Care","volume":"25","author":"Li D. P.","year":"2025","journal-title":"Chinese Journal of Evidence\u2010Based Medicine"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.07.006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz200"},{"issue":"4","key":"e_1_2_7_19_1","first-page":"350","article-title":"Principles of Pain Control in Palliative Care for Adults. Guidance Prepared by a Working Group of the Ethical Issues in Medicine Committee of the Royal College of Physicians","volume":"34","author":"Physicians WGotEIiMCotRCo","year":"2000","journal-title":"Journal of the Royal College of Physicians of London"},{"issue":"1","key":"e_1_2_7_20_1","first-page":"i1","article-title":"Guidance on the Management of Pain in Older People","volume":"42","author":"Abdulla A.","year":"2013","journal-title":"Age and Ageing"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100225"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02198"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2009.0031"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.16-3-254"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.07.006"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.9043"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0807-6"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1188\/20.ONF.228-240"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2008.01.013"},{"issue":"7","key":"e_1_2_7_30_1","article-title":"Opioids for Cancer Pain\u2014An Overview of Cochrane Reviews","volume":"7","author":"Wiffen P. J.","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4368-x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2017.0578"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1678"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60900-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.018531"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-5-28"},{"issue":"2","key":"e_1_2_7_37_1","first-page":"344","article-title":"Nonsteroidal Antiinflammatory Drugs or Acetaminophen for Osteoarthritis of the Hip or Knee? A Systematic Review of Evidence and Guidelines","volume":"31","author":"Wegman A.","year":"2004","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-024-01151-8"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.03.008"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5096"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831060-00009"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010234"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216317711826"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2002.14.2.214"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00157.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-009-0009-1"},{"issue":"1","key":"e_1_2_7_47_1","first-page":"1","article-title":"Pregabalin Combined With Opioids for Managing Neuropathic Pain in Patients With Cancer: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials","volume":"28","author":"Wen C.","year":"2025","journal-title":"Pain Physician"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.8221"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03465"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2020-001038"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv306"},{"key":"e_1_2_7_52_1","volume-title":"Care of Dying Adults in the Last Days of Life","author":"National Clinical Guideline Centre","year":"2015"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyy079"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/29.12.600"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.5362"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909114559769"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/15360288.2019.1708529"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4309-8"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909112448924"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19084907"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909113513063"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2019-001929"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2016.05.013"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.06.024"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-985621"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.08.016"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2004.08.016"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/026921639701100403"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05116-1"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.02.019"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyae008"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2024.0487"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2023.04.009"},{"issue":"3","key":"e_1_2_7_74_1","article-title":"Opioids for the Palliation of Refractory Breathlessness in Adults With Advanced Disease and Terminal Illness","volume":"2016","author":"Barnes H.","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp150893"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.3134"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.20206"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-213681"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.523"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S112484"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2021.2013460"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.709638"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.10.003"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-1058-8"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.05.004"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-017-0264-2"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-684X-9-22"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.09.024"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.11.026"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909115615127"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2018.07.001"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909117707905"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz430"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1136\/spcare-2024-004922"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909119873626"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1080\/J354v18n04_02"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604161"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61115-4"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13622"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.10.284"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70009-3"},{"issue":"1","key":"e_1_2_7_102_1","first-page":"49","article-title":"The Effects of Acupressure on Quality of Life and Dyspnea in Lung Cancer: A Randomized, Controlled Trial","volume":"26","author":"Do\u011fan N.","year":"2020","journal-title":"Alternative Therapies in Health and Medicine"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2025.103236"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1188\/12.ONF.568-577"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-684X-4-5"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0013-6"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800409347556"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909117696723"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909118788643"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0453-x"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2018.01.005"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2020-002382"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.12.028"},{"issue":"1","key":"e_1_2_7_114_1","first-page":"13","article-title":"Chinese National Guideline on Diagnosis and Management of Cough (2021)","volume":"45","author":"Asthma Group of Chinese Thoracic Society","year":"2022","journal-title":"Chinese Journal of Tuberculosis and Respiratory Diseases"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00432-0"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006058301100206"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.055"},{"issue":"13","key":"e_1_2_7_118_1","first-page":"975","article-title":"Efficacy of Compound Pholcodine Syrup and Compound Codeine Phosphate Oral Solution on Lung Cancer\u2010Related Cough","volume":"103","author":"Chen M. T.","year":"2023","journal-title":"National Medical Journal of China"},{"issue":"5","key":"e_1_2_7_119_1","first-page":"593","article-title":"Comparison of Clinical Effects of Different Doses of Ambroxol Hydrochloride in the Treatment of Elderly Patients With Chronic Bronchitis","volume":"29","author":"Qiao J. J.","year":"2018","journal-title":"Journal of Aerospace Medicine"},{"issue":"10","key":"e_1_2_7_120_1","first-page":"14","article-title":"The Curative Effect of Tiotropium Combined With Ambroxol Hydrochloride in the Treatment of Senile Acute COPD","volume":"13","author":"Yu Q. B.","year":"2016","journal-title":"North Pharm"},{"issue":"3","key":"e_1_2_7_121_1","first-page":"468","article-title":"Clinical Effect Analysis of Antibiotics Combined With Ambroxol in the Treatment of Acute Exacerbation of Elderly Chronic Bronchitis","volume":"7","author":"Li F. Y.","year":"2018","journal-title":"Journal of Cardiovascular Surgery"},{"issue":"9","key":"e_1_2_7_122_1","first-page":"106","article-title":"Clinical Analysis of Ambroxol Hydrochloride in the Treatment of Acute Exacerbation of Elderly Chronic Bronchitis","volume":"13","author":"Lu Z. Q.","year":"2019","journal-title":"Chinese Journal of Modern Drug Application"},{"issue":"6","key":"e_1_2_7_123_1","first-page":"877","article-title":"Effect of Carbocisteine Tablets Combined With CPAP in the Treatment of Elderly Patients With OSAHS","volume":"46","author":"Ji G. N.","year":"2022","journal-title":"Guizhou Medical Journal"},{"issue":"23","key":"e_1_2_7_124_1","first-page":"175","article-title":"Clinical Observation of Carbocisteine Oral Solution in the Treatment of Pneumonia Patients Aged Over 65 Years","volume":"7","author":"Zhang J.","year":"2012","journal-title":"China Practical Medicine"},{"issue":"16","key":"e_1_2_7_125_1","first-page":"176","article-title":"Clinical Effect Observation of Ambroxol Hydrochloride in the Treatment of Elderly Chronic Bronchitis at Acute Stage","volume":"13","author":"Li S. H.","year":"2015","journal-title":"Guide of China Medicine"},{"issue":"3","key":"e_1_2_7_126_1","first-page":"126","article-title":"Clinical Analysis of 64 Cases of Elderly Chronic Bronchitis","volume":"29","author":"Chai H. P.","year":"2015","journal-title":"Chinese Primary Health Care"},{"issue":"7","key":"e_1_2_7_127_1","first-page":"50","article-title":"Effect of Ambroxol Hydrochloride Combined With Ceftriaxone Sodium in the Treatment of Elderly Chronic Bronchitis","volume":"14","author":"He Y.","year":"2021","journal-title":"Chinese Journal of Clinical Rational Drug Use"},{"issue":"1","key":"e_1_2_7_128_1","article-title":"Interventions for Noisy Breathing in Patients Near to Death","volume":"2008","author":"Wee B.","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.7.875"},{"issue":"13","key":"e_1_2_7_130_1","first-page":"86","article-title":"Analysis of the Application Effect of Ambroxol Hydrochloride Combined With Ceftriaxone Sodium in the Treatment of Chronic Bronchitis in the Elderly","volume":"20","author":"Yu C. H.","year":"2025","journal-title":"China Practical Medicine"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2620-5"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-024-00774-3"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-020-00946-y"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-024-00780-5"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4931284"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15194765"},{"issue":"1","key":"e_1_2_7_137_1","first-page":"1","article-title":"Expert Consensus on the Diagnosis and Management of Hemoptysis","volume":"19","author":"Expert Consensus Writing Group on the Diagnosis and Management of Hemoptysis, Beijing Medical Association","year":"2020","journal-title":"Chinese Journal of Respiratory and Critical Care Medicine"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1985.11699024"},{"key":"e_1_2_7_139_1","unstructured":"National Health Commission of the People's Republic of China Notice of the General Office of the National Health Commission on Issuing the Practice Guidelines for Hospice Care (2025 Edition)(National Health Commission of the People's Republic of China 2025) https:\/\/www.nhc.gov.cn\/yzygj\/c100068\/202508\/77bbbf599f894e40bbeffff938e8a577.shtml."},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.3795"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00219-6"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.202"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820690532"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00398-0"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008291825695"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.297"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.4.762"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53307.x"},{"issue":"2","key":"e_1_2_7_149_1","first-page":"43","article-title":"Risks and Benefits of Various Therapies for Cancer Anorexia","volume":"49","author":"Schmoll E.","year":"1992","journal-title":"Oncology"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160208800406"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13500"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12292"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2013.0324"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197406)33:6<1607::AID-CNCR2820330620>3.0.CO;2-V"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.3926"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(89)90354-4"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82120-8"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.10.3299"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0739-7"},{"key":"e_1_2_7_160_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0225"},{"key":"e_1_2_7_161_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318237d626"},{"key":"e_1_2_7_162_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050283"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-015-0455-3"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq048"},{"issue":"11","key":"e_1_2_7_165_1","article-title":"Antiemetics for Adults for Prevention of Nausea and Vomiting Caused by Moderately or Highly Emetogenic Chemotherapy: A Network Meta\u2010Analysis","volume":"2021","author":"Piechotta V.","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_166_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a010675"},{"key":"e_1_2_7_167_1","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-100107736"},{"key":"e_1_2_7_168_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-029942"},{"key":"e_1_2_7_169_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2017.0159"},{"key":"e_1_2_7_170_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.1052"},{"key":"e_1_2_7_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.10.023"},{"key":"e_1_2_7_172_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2012.0111"},{"key":"e_1_2_7_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2004.03441.x"},{"key":"e_1_2_7_174_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta11510"},{"key":"e_1_2_7_175_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.100"},{"key":"e_1_2_7_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12441"},{"key":"e_1_2_7_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12866"},{"key":"e_1_2_7_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840100611"},{"key":"e_1_2_7_179_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6464.275"},{"key":"e_1_2_7_180_1","unstructured":"BC Centre for Palliative Care Pain\u2014B.C. Inter\u2010Professional Palliative Symptom Management Guidelines(BC Centre for Palliative Care 2019)."},{"key":"e_1_2_7_181_1","volume-title":"Palliative Medicine Handbook","author":"Back I. N.","year":"2001"},{"key":"e_1_2_7_182_1","volume-title":"Oxford Handbook of Palliative Care","author":"Watson M. S.","year":"2005"},{"key":"e_1_2_7_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.04.027"},{"key":"e_1_2_7_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2025.103945"},{"key":"e_1_2_7_185_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.19485"},{"key":"e_1_2_7_186_1","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2023.00829"},{"key":"e_1_2_7_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2023.11.050"},{"key":"e_1_2_7_188_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.4.476"},{"key":"e_1_2_7_189_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.1.148"},{"key":"e_1_2_7_190_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-199308000-00004"},{"key":"e_1_2_7_191_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830500304"},{"key":"e_1_2_7_192_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199411000-00007"},{"key":"e_1_2_7_193_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1988.tb00707.x"},{"key":"e_1_2_7_194_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709025060"},{"key":"e_1_2_7_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90924-5"},{"key":"e_1_2_7_196_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2745"},{"key":"e_1_2_7_197_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12213"},{"key":"e_1_2_7_198_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002116.pub2"},{"key":"e_1_2_7_199_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2019-101301"},{"issue":"5","key":"e_1_2_7_200_1","first-page":"441","article-title":"Medical Prevention and Treatment of Acute and Chronic Radiation Induced Enteritis\u2014Is There Any Proven Therapy? A Short Review","volume":"46","author":"Zimmerer T.","year":"2008","journal-title":"German Journal of Gastroenterology"},{"key":"e_1_2_7_201_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.132"},{"issue":"9","key":"e_1_2_7_202_1","article-title":"Mu\u2010Opioid Antagonists for Opioid\u2010Induced Bowel Dysfunction in People With Cancer and People Receiving Palliative Care","volume":"9","author":"Candy B.","year":"2022","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(99)00157-8"},{"key":"e_1_2_7_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2023.12.010"},{"issue":"7","key":"e_1_2_7_205_1","article-title":"Lactulose Versus Polyethylene Glycol for Chronic Constipation","volume":"2010","author":"Lee\u2010Robichaud H.","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_206_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311835"},{"key":"e_1_2_7_207_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001222"},{"key":"e_1_2_7_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2017.08.022"},{"key":"e_1_2_7_209_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00381"},{"key":"e_1_2_7_210_1","doi-asserted-by":"publisher","DOI":"10.5114\/mp.2025.148746"},{"key":"e_1_2_7_211_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy148"},{"key":"e_1_2_7_212_1","volume-title":"Urinary Incontinence and Pelvic Organ Prolapse in Women: Management","author":"National Institute for Health and Care Excellence (NICE)","year":"2019"},{"key":"e_1_2_7_213_1","unstructured":"C. K.Harding M. C.Lapitan andS.Arlandis European Association of Urology Guidelines on non\u2010neurogenic female LUTS (European Association of Urology(2023) https:\/\/uroweb.org\/guidelines\/non-neurogenic-female-luts."},{"key":"e_1_2_7_214_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12194"},{"key":"e_1_2_7_215_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2042-x"},{"key":"e_1_2_7_216_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-018-0892-0"},{"key":"e_1_2_7_217_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22945"},{"key":"e_1_2_7_218_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12464"},{"issue":"19","key":"e_1_2_7_219_1","first-page":"S608","article-title":"Health\u2010Related Quality of Life of Patients Receiving Extended\u2010Release Tolterodine for Overactive Bladder","volume":"8","author":"Kelleher C. J.","year":"2002","journal-title":"American Journal of Managed Care"},{"key":"e_1_2_7_220_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07710.x"},{"key":"e_1_2_7_221_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.509582"},{"key":"e_1_2_7_222_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2009.09.2062"},{"key":"e_1_2_7_223_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02209.x"},{"key":"e_1_2_7_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.02.2700"},{"key":"e_1_2_7_225_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-005-0012-8"},{"key":"e_1_2_7_226_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12088"},{"key":"e_1_2_7_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2009.11.005"},{"key":"e_1_2_7_228_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1908-1"},{"key":"e_1_2_7_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.02.030"},{"issue":"6","key":"e_1_2_7_230_1","first-page":"677","article-title":"Assessing Preference\u2010Based Outcome Measures for Overactive Bladder: An Evaluation of Patient\u2010Reported Outcome Data From the BESIDE Clinical Trial","volume":"10","author":"Herdman M.","year":"2017","journal-title":"Patient"},{"key":"e_1_2_7_231_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000574"},{"key":"e_1_2_7_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.07.013"},{"key":"e_1_2_7_233_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01517-5"},{"key":"e_1_2_7_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2019.10.019"},{"key":"e_1_2_7_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.09.091"},{"key":"e_1_2_7_236_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20230392"},{"key":"e_1_2_7_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.02.006"},{"key":"e_1_2_7_238_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.5232"},{"key":"e_1_2_7_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2021.05.017"},{"issue":"6","key":"e_1_2_7_240_1","first-page":"1547","article-title":"Potential Role of Bupropion Sustained Release for Cancer\u2010Related Fatigue: A Double\u2010Blind, Placebo\u2010Controlled Study","volume":"19","author":"Ashrafi F.","year":"2018","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"e_1_2_7_241_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta17070"},{"key":"e_1_2_7_242_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1985.tb08081.x"},{"key":"e_1_2_7_243_1","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-57596"},{"key":"e_1_2_7_244_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.025"},{"key":"e_1_2_7_245_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02120216"},{"key":"e_1_2_7_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00187-5"},{"key":"e_1_2_7_247_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1075-122X.2006.00218.x"},{"key":"e_1_2_7_248_1","doi-asserted-by":"publisher","DOI":"10.4081\/monaldi.2004.692"},{"key":"e_1_2_7_249_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.7.737"},{"key":"e_1_2_7_250_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.10.1686"},{"key":"e_1_2_7_251_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200002000-00009"},{"key":"e_1_2_7_252_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.070"},{"key":"e_1_2_7_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.068"},{"key":"e_1_2_7_254_1","doi-asserted-by":"publisher","DOI":"10.1017\/S104161020100761X"},{"key":"e_1_2_7_255_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28569"},{"key":"e_1_2_7_256_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1996.tb09850.x"},{"key":"e_1_2_7_257_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-2175-1"},{"key":"e_1_2_7_258_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181c796eb"},{"key":"e_1_2_7_259_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-6618-9"},{"key":"e_1_2_7_260_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.169.4.440"},{"key":"e_1_2_7_261_1","article-title":"Drug Therapy for Symptoms Associated With Anxiety in Adult Palliative Care Patients","volume":"10","author":"Candy B.","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_262_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2011-000093"},{"key":"e_1_2_7_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.03.026"},{"issue":"20","key":"e_1_2_7_264_1","first-page":"2382","article-title":"Methylphenidate Versus Placebo for Treating Fatigue in Patients With Advanced Cancer: Randomized, Double\u2010Blind, Multicenter, Placebo\u2010Controlled Trial","volume":"42","author":"Stone P. C.","year":"2024","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"e_1_2_7_265_1","first-page":"106","article-title":"Efficacy and Safety of Zolpidem in Treatment of Primary Insomnia in Chinese Elderly: An Open, Self\u2010Controlled, Multicenter Study","volume":"43","author":"Wang X. Q.","year":"2010","journal-title":"Chinese Journal of Psychiatry"},{"key":"e_1_2_7_266_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.2.225"},{"key":"e_1_2_7_267_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-859X-11-15"},{"key":"e_1_2_7_268_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-51"},{"key":"e_1_2_7_269_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175138"},{"key":"e_1_2_7_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.09.035"},{"key":"e_1_2_7_271_1","doi-asserted-by":"publisher","DOI":"10.1080\/15360288.2020.1784353"},{"key":"e_1_2_7_272_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.7491"},{"key":"e_1_2_7_273_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0242"},{"key":"e_1_2_7_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2017.03.014"},{"key":"e_1_2_7_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.09.023"},{"key":"e_1_2_7_276_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951505050479"},{"issue":"1","key":"e_1_2_7_277_1","article-title":"Drug Therapy for Delirium in Terminally Ill Adults","volume":"1","author":"Finucane A. M.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"e_1_2_7_278_1","article-title":"Benzodiazepines for Treatment of Patients With Delirium Excluding Those Who Are Cared for in an Intensive Care Unit","volume":"2","author":"Li Y.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_279_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520975"},{"key":"e_1_2_7_280_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.11468"},{"key":"e_1_2_7_281_1","doi-asserted-by":"publisher","DOI":"10.1080\/15360288.2016.1231733"},{"issue":"10","key":"e_1_2_7_282_1","article-title":"Exploring the Association Between Intravenous Lorazepam and Mortality Among Older Hospitalized Patients With and Without Cognitive Impairment","volume":"16","author":"Flaherty J. H.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_7_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2025.07.027"},{"key":"e_1_2_7_284_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.02.057"},{"key":"e_1_2_7_285_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1508375"},{"issue":"15","key":"e_1_2_7_286_1","first-page":"7362","article-title":"Treatment of Fever and Associated Symptoms in the Emergency Department: Which Drug to Choose?","volume":"27","author":"Franceschi F.","year":"2023","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"4","key":"e_1_2_7_287_1","first-page":"302","article-title":"Meta\u2010Analysis of Randomized Controlled Trial Research Literature of Traditional Chinese Medicine for Cancer\u2010Related Fatigue","volume":"36","author":"Zhu Q.","year":"2015","journal-title":"Journal of Naval Medicine"},{"key":"e_1_2_7_288_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121919"},{"key":"e_1_2_7_289_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11211"},{"key":"e_1_2_7_290_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0373"},{"key":"e_1_2_7_291_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.1444"},{"key":"e_1_2_7_292_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8506"},{"key":"e_1_2_7_293_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2020-002454"},{"key":"e_1_2_7_294_1","doi-asserted-by":"publisher","DOI":"10.3310\/GJPS6321"},{"issue":"15","key":"e_1_2_7_295_1","first-page":"1030","article-title":"Clinical Trial for Small Dose\u2010Short Term of Prednisone on Advanced Cancer Patients With Cancer Related Fatigue","volume":"23","author":"Liu Q. X.","year":"2016","journal-title":"Chinese Journal of Cancer Prevention and Treatment"},{"key":"e_1_2_7_296_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.4661"},{"issue":"12","key":"e_1_2_7_297_1","first-page":"4017","article-title":"Reticular Meta\u2010Analysis of Traditional Chinese Medicine Injections in the Treatment of Cancer\u2010Related Fatigue","volume":"25","author":"Xu K. Y.","year":"2023","journal-title":"Modernization of Traditional Chinese Medicine and Materia Medica\u2014World Science and Technology"},{"issue":"1","key":"e_1_2_7_298_1","first-page":"39","article-title":"Clinical Research of Shengmai Injection in Improving Qi Deficiency Syndrome in Advanced Breast Cancer Patients","volume":"22","author":"Wu Y. F.","year":"2015","journal-title":"China Practical Medicine"},{"issue":"4","key":"e_1_2_7_299_1","first-page":"486","article-title":"Effect of Shengmai Injection on Side\u2010Effects of Chemotherapy for Aged Patients With Malignant Tumor","volume":"30","author":"Fang P.","year":"2009","journal-title":"Academic Journal of Chinese PLA Medical School"},{"issue":"5","key":"e_1_2_7_300_1","first-page":"1035","article-title":"Treatment of 33 Cases of Advanced Gastric Cancer With Shengmai Injection Combined With Chemotherapy","volume":"29","author":"Hao S. L.","year":"2014","journal-title":"Guangming Journal of Chinese Medicine"}],"container-title":["Journal of Evidence-Based Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.70160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jebm.70160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.70160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:02:48Z","timestamp":1790326968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jebm.70160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":299,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jebm.70160"],"URL":"https:\/\/doi.org\/10.1111\/jebm.70160","archive":["Portico"],"relation":{},"ISSN":["1756-5383","1756-5391"],"issn-type":[{"value":"1756-5383","type":"print"},{"value":"1756-5391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70160"}}