{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:59:10Z","timestamp":1790330350439,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically analyze the comorbidity status, polypharmacy patterns, and potential medication risks among hypertensive patients attending cardiology departments in tertiary hospitals in China based on real\u2010world outpatient prescription data, providing real\u2010world evidence to describe the medication complexity in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional study design was employed. Prescription data of hypertensive patients from the cardiology outpatient departments of 56 tertiary hospitals in mainland China in 2017 were extracted. Diagnosis data, medication data, potentially inappropriate medication (PIM) and potential drug\u2013drug interactions (pDDI) were analyzed. Continuous variables were compared using\n                      <jats:italic>t<\/jats:italic>\n                      \u2011tests or Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      tests and reported as mean \u00b1 standard deviation or median (interquarile range). Linear regression assessed age\u2011related trends in medication counts. All tests were two\u2011sided with \u03b1 = 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>83.3% of patients had at least one other comorbid condition. The average number of medications per patient was 7.44 \u00b1 5.98, showing a positive correlation with age. Among elderly patients, 10%\u201315% were exposed to PIMs, and we identified 12 clinically significant pDDI pairs in the cardiology outpatient prescription scenario.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multimorbidity and polypharmacy are prevalent among hypertensive patients attending cardiology departments in tertiary hospitals in China. These findings serve as a historical baseline rather than direct clinical guidance. Based on the high prevalence of PIMs in elderly patients and typical clinically significant pDDI identified in this cohort, targeted medication safety strategies (including tailored Medication Therapy Management for multimorbid hypertensive patients and appropriate deprescribing of high\u2010risk agents in the elderly) are suggested to optimize patient\u2010centered comorbidity management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70167","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:44:04Z","timestamp":1786002244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Descriptive Analysis of the Medication Complexity Among Hypertensive Patients in Tertiary Hospital Cardiology Departments in China: A Real\u2010World Study"],"prefix":"10.1111","volume":"19","author":[{"given":"Yuxiang","family":"Pei","sequence":"first","affiliation":[{"name":"Executive Office Medical Supplies Center of People's Liberation Army General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhe","family":"Bian","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wan","sequence":"additional","affiliation":[{"name":"Executive Office Medical Supplies Center of People's Liberation Army General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00559-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.11.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01330-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2025.100808"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17082618"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-030584"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57121288"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-091997"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000000818"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1176170"},{"issue":"2","key":"e_1_2_7_12_1","doi-asserted-by":"crossref","DOI":"10.1590\/0034-7167-2022-0785","article-title":"Polypharmacy, Potentially Inappropriate Medications and Associated Factors Among Older Adults With Hypertension in Primary Care","volume":"76","author":"Sangaleti C. 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