{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:59:35Z","timestamp":1790330375201,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202206557005"],"award-info":[{"award-number":["202206557005"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate harms reporting practices in placebo\u2010controlled randomized clinical trials (RCTs) of Chinese herbal medicine (CHM) formulas published in Quartile 1 (Q1) English\u2010language and Tier\u20101 Chinese journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic survey evaluated harms reporting in CHM formula RCTs. We systematically identified eligible RCTs published in English\u2010language journals Q1 (2024 Journal Citation Reports) and Chinese Tier\u20101 journals (2023 Traditional Chinese Medicine ranking). Two reviewers independently evaluated harms reporting using items derived from the CONSORT Extension for Harms (CONSORT Harms) recommendations and CHM formula\u2010specific reporting elements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 96 eligible RCTs (49 English Q1; 47 Chinese Tier\u20101), only 19.8% (\n                      <jats:italic>n<\/jats:italic>\n                      = 19) of trials had a published protocol, with a significantly higher proportion in English Q1 journals (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Only one trial explicitly reported adherence to the CONSORT Harms extension (2004 or 2022). Syndrome differentiation was significantly more frequent in Chinese Tier\u20101 journals than in English Q1 journals (76.6%\u00a0vs. 38.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Sixty\u2010seven percent of studies (\n                      <jats:italic>n<\/jats:italic>\n                      = 64) did not report methods for assessing the relationship between harms and interventions, and 15.6% (\n                      <jats:italic>n<\/jats:italic>\n                      = 15) relied solely on clinical judgment. Eighty percent of studies (\n                      <jats:italic>n<\/jats:italic>\n                      = 77) did not report statistical methods for harms analysis. In the results section, 62% (\n                      <jats:italic>n<\/jats:italic>\n                      = 59) did not present harms data in tables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Harms reporting in CHM formula RCTs remains inadequate. Routine adoption of the CONSORT Harms framework, together with CHM formula\u2010specific harms reporting elements, is needed to improve transparency and facilitate the interpretation of harms data in CHM formula research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70174","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T03:10:27Z","timestamp":1786677027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inadequate Reporting of Harms in RCTs of Chinese Herbal Medicine Formulas: A Systematic Survey of Leading Medical Journals"],"prefix":"10.1111","volume":"19","author":[{"given":"Rui","family":"Zheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing University of Chinese Medicine  Beijing China"},{"name":"Department of Health Research Methods Evidence, and Impact, McMaster University  Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing University of Chinese Medicine  Beijing China"},{"name":"School of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Jin","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based and Translational Medicine Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Chen","sequence":"additional","affiliation":[{"name":"Dongfang Hospital, Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongcai","family":"Shang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing University of Chinese Medicine  Beijing China"},{"name":"Dongfang Hospital, Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods Evidence, and Impact, McMaster University  Hamilton 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