{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:59:31Z","timestamp":1790330371733,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72304009"],"award-info":[{"award-number":["72304009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Clinical trials are regarded as an essential method for developing new treatments and giving patients access to potentially effective medications that are still being studied. This study aimed to evaluate acceptance of participating in clinical trials of new drugs and to further explore the associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A population\u2010based cross\u2010sectional study was conducted in China from June 20 to August 31, 2022. We collected demographic data and used visual analog scale scores to assess the public's willingness to accept clinical trials of new drugs (range 0\u2013100). Linear regression analysis was adopted to evaluate the factors related to attitudes toward clinical trials of new drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This survey contained 19,710 valid questionnaires to investigate acceptance of participating in clinical trials of new drugs. Participants showed low willingness to accept clinical trials of new drugs, with a mean score of 44.69 out of 100. The results showed that rural residence (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 3.00), western China (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 3.15), being married (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 2.93), older age (31\u201359 years [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 3.84], \u226560 years [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 7.71]), having cancer or rare diseases (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 5.15), higher monthly household income (&gt;6000 yuan [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 1.76]), medical\u2010related occupations (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 8.01), anxiety status (moderate anxiety [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 1.83]), moderate to severe anxiety [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 2.66]), perceived stress (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.51), health literacy (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.21), self\u2010efficacy (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.34), and media use (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.42) were associated with higher acceptance of participating in clinical trials of new drugs. However, central China (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = \u20131.65), female sex (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = \u20132.29), chronic diseases (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = \u20132.45), and medical insurance (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = \u20133.78) were associated with lower acceptance of participating in clinical trials of new drugs. Subgroup analysis demonstrated consistent trends across age and chronic disease subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This reveales low public willingness to accept clinical trials of new drugs. The willingness is affected by marital status, occupation, area of residence, income, health insurance, physical and mental health status, media use, and health literacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70176","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:03:12Z","timestamp":1787749392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Affecting Acceptance of Participating in Clinical Trials of New Drugs: A National Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"19","author":[{"given":"Shujie","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Han","sequence":"additional","affiliation":[{"name":"School of Health Policy and Management Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nursing the Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine, Zhejiang University  Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai\u2010kit","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115476"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143893"},{"key":"e_1_2_8_4_1","volume-title":"Global Trends in R&D 2024: Activity, Productivity, and Enablers","author":"IQVIA Institute for Human Data Science","year":"2024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-022-00156-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaa155"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-11197-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5617575"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2021.106315"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.6245"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-014-1339-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031305"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.4553"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.105"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2019.03.013"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.27792"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774515571917"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10810730.2017.1290715"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1276536"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-46979-z"},{"issue":"2","key":"e_1_2_8_21_1","first-page":"e91","article-title":"Development and Validation of a New Short\u2010Form Health Literacy Instrument (HLS\u2010SF12) for the General Public in Six Asian Countries","volume":"3","author":"Duong T. 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