{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:59:27Z","timestamp":1790330367255,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373675"],"award-info":[{"award-number":["82373675"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473720"],"award-info":[{"award-number":["82473720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515010972"],"award-info":[{"award-number":["2024A1515010972"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically evaluate the correlations between atherogenic index of plasma (AIP) and the morbidity and mortality of cardiovascular disease (CVD) and investigate the potential dose\u2013response relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We comprehensively searched the PubMed, Embase, and Web of Science Core Collection, CNKI, WanFang, and VIP for relevant literature until January 31, 2026. The included studies were cohort studies. The pooled relative risk (RR) and 95% confidence interval (CI) for dose\u2013response relationships were calculated. The linear\/nonlinear relationships were evaluated by using restricted cubic splines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 24 studies were included for the analysis. The pooled RRs for CVD morbidity and mortality in the highest versus lowest AIP group were 1.35 (95% CI: 1.25 to 1.45) and 1.49 (95% CI: 1.19 to 1.87), respectively. For per 1\u2010unit increase in AIP, the risk of CVD morbidity and mortality increased by 47% (RR = 1.47, 95% CI: 1.32 to 1.64) and 42% (RR = 1.42, 95% CI: 1.18 to 1.71), respectively. Dose\u2013response results showed linear associations between AIP and CVD morbidity (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>non\u2010linearity<\/jats:sub>\n                      = 0.659), as well as between AIP and CVD mortality (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>non\u2010linearity<\/jats:sub>\n                      = 0.619).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This dose\u2013response meta\u2010analysis revealed a correlation between elevated AIP and the morbidity and mortality of CVD. The association has a dose\u2013response profile between AIP and CVD morbidity, suggesting that AIP may serve as a potential predictor of CVD and provide an important basis for early clinical identification and intervention in populations at high risk of CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70179","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:20:48Z","timestamp":1787116848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Atherogenic Index of Plasma and Risk of Cardiovascular Disease: A Dose\u2013Response Meta\u2010Analysis of Cohort Studies"],"prefix":"10.1111","volume":"19","author":[{"given":"Taifeng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinliang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqi","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics College of Public Health Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002927"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.068"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.02.053"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318798059"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(01)00263-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02144-y"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0315396"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-021-01505-w"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02370-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02350-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02198-y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02582-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr265"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.19.1690"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn005"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj141"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-011-9548-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.07.019"},{"key":"e_1_2_7_27_1","first-page":"470","article-title":"Bias in Meta\u2010Analysis Detected by a Simple, Graphical Test. Graphical Test Is Itself Biased","volume":"316","author":"Irwig L.","year":"1998","journal-title":"Bmj"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.03.017"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-02374-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-025-01715-7"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.23-406"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2023.11.002"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03677-0"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02255-1"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02314-y"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01522-8"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-022-01670-6"},{"key":"e_1_2_7_38_1","first-page":"8022","article-title":"A J\u2010Shaped Relationship Between the Atherogenic Index of Plasma and New\u2010Onset Myocardial Infarction in Hypertensive Patients With Obstructive Sleep Apnea: A Cohort Study","volume":"26","author":"Cai X. T.","year":"2022","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2021.09.003"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093231"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01393-5"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01360-1"},{"key":"e_1_2_7_43_1","volume-title":"Association of Dyslipidemia and Lipidomics With Stroke in Populations in Northeast China","author":"Jiang M. H.","year":"2024"},{"key":"e_1_2_7_44_1","first-page":"54","article-title":"Association Between Plasma Atherogenic Index and Cardiovascular Disease Risk in Elderly Hypertensive Community Residents in Kunshan: A Cohort Study","volume":"28","author":"Lu B.","year":"2024","journal-title":"Journal of Clinical Medicine in Practice"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2025.112315"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2025.100936"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02941-z"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02359-z"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1150563"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03451-0"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177499"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2021.11.005"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.120.000096"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.061"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2017.22.3.158"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/biom.13342"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00377-8"}],"container-title":["Journal of Evidence-Based Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.70179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jebm.70179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.70179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:02:56Z","timestamp":1790326976000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jebm.70179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jebm.70179"],"URL":"https:\/\/doi.org\/10.1111\/jebm.70179","archive":["Portico"],"relation":{},"ISSN":["1756-5383","1756-5391"],"issn-type":[{"value":"1756-5383","type":"print"},{"value":"1756-5391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]},"assertion":[{"value":"2025-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70179"}}