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We quantified the global burden and trends of key CKM\u2010related conditions and high body mass index (BMI)\u2010attributable burden among WRA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using global burden of disease data from 1990 to 2021, we quantified six CKM\u2010related disease outcomes and the burden attributable to high BMI. Trends were assessed using estimated annual percentage changes (EAPCs), and burden was projected to 2050 using Bayesian age\u2013period\u2013cohort models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2021, diabetes mellitus had the highest incidence rate (273.37 per 100,000 population; 95% uncertainty interval [UI], 204.50\u2013353.52), ischemic heart disease the highest death rate (8.48 per 100,000 population; 95% UI: 7.68\u20139.35), high BMI the highest attributable disability\u2010adjusted life\u2010year (DALY) rate (641.53 per 100,000 population; 95% UI: 283.14\u2013998.09), and chronic kidney disease the highest prevalence rate (6805.22; 95% UI: 5319.94\u20138575.90). From 1990 to 2021, the age\u2010standardized death rate attributable to high BMI increased (EAPC, 0.43%; 95% confidence interval [CI]: 0.37%\u20130.50%), whereas the age\u2010standardized DALY rate (ASDALYR) for stroke declined (\u22121.93%; 95% CI: \u22122.01% to \u22121.86%). Low\u2013middle sociodemographic index regions had the highest ASDALYR in 2021 (2757.18; 95% UI: 2056.45\u20133505.64). Under historical\u2010trend assumptions, high\u2010BMI\u2010attributable DALYs were projected to remain dominant through 2050 (1051.49; 95% UI: 235.36\u20131868.06), with the fastest projected increase in lower extremity peripheral arterial disease (3.39%; 95% CI: 3.13%\u20133.66%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among WRA, CKM\u2010related burden was substantial and varied across sociodemographic index quintiles. These findings support intensified adiposity control and context\u2010specific prevention to reduce future burden through 2050.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70180","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T07:31:20Z","timestamp":1786433480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global Burden of Key Components of Cardiovascular\u2013Kidney\u2013Metabolic Syndrome Among Women of Reproductive Age, 1990\u20132021"],"prefix":"10.1111","volume":"19","author":[{"given":"Cuiping","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Department of Endocrinology Huadong Hospital Affiliated to Fudan University  Shanghai 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