{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:59:20Z","timestamp":1790330360393,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270384"],"award-info":[{"award-number":["82270384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570296"],"award-info":[{"award-number":["82570296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individuals with prediabetes have a higher cardiovascular disease (CVD) risk than those with normoglycemia. Identifying high\u2010risk subgroups is crucial for targeted prevention. While the triglyceride\u2010glucose index (TyG) and a body shape index (ABSI) are independently linked to CVD risk, their combined utility in individuals with prediabetes remains unexplored. This study aimed to investigate whether concurrent high TyG and ABSI confer an additive CVD risk in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 6833 UK Biobank participants with prediabetes and no baseline CVD. Cox proportional hazards models were used to assess the associations between TyG, ABSI, and CVD incidence, adjusting for sociodemographic and metabolic confounders. Predictive performance was evaluated using the area under the curve (AUC) of receiver operating characteristic curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median 9.5\u2010year follow\u2010up, 840 participants developed CVD. Elevated TyG (hazard ratio [HR] = 1.09, 95% confidence interval [CI]: 1.01\u20131.25) and the highest ABSI quartile (HR = 1.54, 95% CI: 1.22\u20131.94) showed independent associations with CVD risk. Combined high TyG\/high ABSI conferred an additive risk (HR = 1.65, 95% CI: 1.24\u20132.20), an effect more pronounced in hypertensive participants than in normotensive individuals (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction = 0.018). The dual\u2010marker method showed better discriminative performance for CVD (AUC = 0.685) than TyG or ABSI alone (TyG: 0.661; ABSI: 0.608; DeLong test\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The joint elevation of TyG and ABSI identifies individuals with prediabetes at higher CVD risk independent of conventional indicators, especially within hypertensive subgroups, enabling targeted monitoring and intervention to alleviate the CVD burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70185","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:59:38Z","timestamp":1787637578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Joint Association of Triglyceride\u2010Glucose Index and a Body Shape Index With Risk of Cardiovascular Disease Among Adults With Prediabetes"],"prefix":"10.1111","volume":"19","author":[{"given":"Feipeng","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People's Hospital of Shunde, Foshan) Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People's Hospital of Shunde, Foshan) Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Practice The Eighth Affiliated Hospital Southern Medical University (The First People's Hospital of Shunde, Foshan) Foshan 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Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People's Hospital of Shunde, Foshan) Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People's Hospital of Shunde, Foshan) Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Eighth Affiliated Hospital Southern Medical University (The First People's Hospital of Shunde, Foshan) Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Scientific Research and Education The Eighth Affiliated Hospital Southern Medical University (The First People's Hospital of Shunde, Foshan) Foshan 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