{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:59:12Z","timestamp":1790330352526,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272599;82302858"],"award-info":[{"award-number":["82272599;82302858"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["24NSFSC1537"],"award-info":[{"award-number":["24NSFSC1537"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["242102310183"],"award-info":[{"award-number":["242102310183"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exercise and self\u2010management are first\u2010line for knee osteoarthritis (KOA), but evidence on internet\u2010based telerehabilitation comparing specific exercises is limited. We compared a 12\u2010week internet\u2010based neuromuscular exercise (NE) program and a quadriceps exercise (QE) program in community\u2010dwelling patients with symptomatic KOA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, single\u2010blind randomized trial compared 12\u2010week internet\u2010based NE versus QE in community\u2010dwelling adults with symptomatic KOA. The primary outcome: the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain. Secondary outcomes: WOMAC function, daily activity, pressure pain threshold, self\u2010efficacy, Timed Up and Go, and 6\u2010Min Walk Test. Subjective outcomes were assessed at 0, 6, 12 weeks; objective outcomes were assessed at 0, 12 weeks. Generalized estimating equations with group, time, and group\u2010by\u2010time terms were used for intention\u2010to\u2010treat analyses, adjusted for age, sex, body mass index, and the baseline value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 74 randomized participants (NE = 37, QE = 37), 62 completed the 12\u2010week assessment (16.2% discontinued; 18.9% in the NE group, 13.5% in the QE group). Enrollment was below the planned 53 participants per group. At 12 weeks, the adjusted between\u2010group difference in WOMAC pain change was \u22121.0 points (95% confidence interval [CI], \u22122.4 to 0.4;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.150; Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      = \u22120.34); at 6 weeks, it was \u22120.8 points (95% CI, \u22121.9 to 0.4;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.188; Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      = \u22120.33). No statistically significant between\u2010group differences were found in secondary outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This under\u2010enrolled trial found no significant difference between NE and QE in WOMAC pain at 12 weeks. Both groups showed within\u2010group improvement, but equivalence was not established. Findings should be interpreted cautiously due to limited statistical power.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70187","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:31:33Z","timestamp":1788769893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Internet\u2010Based Neuromuscular Versus Quadriceps Exercise on Pain and Function in Patients With Knee Osteoarthritis: A Single\u2010Blind Randomized Controlled Trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Haiming","family":"Wang","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Department The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Center of Rehabilitation Engineering Technology Research  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine West China School of Medicine\/West China Hospital Sichuan University  Chengdu China"},{"name":"Rehabilitation Key Laboratory of Sichuan Province West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine West China School of Medicine\/West China Hospital Sichuan University  Chengdu China"},{"name":"Rehabilitation Key Laboratory of Sichuan Province West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengsen","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine West China School of Medicine\/West China Hospital Sichuan University  Chengdu China"},{"name":"Rehabilitation Key Laboratory of Sichuan Province West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine West China School of Medicine\/West China Hospital Sichuan University  Chengdu China"},{"name":"Rehabilitation Key Laboratory of Sichuan Province West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00163-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.07.019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24131"},{"issue":"12","key":"e_1_2_9_8_1","article-title":"Exercise for Osteoarthritis of the Knee","volume":"12","author":"Lawford B. 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