{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:59:12Z","timestamp":1790330352058,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Published meta\u2010analytic results should be reproducible from information available to readers. We assessed the numerical reproducibility of pairwise meta\u2010analytic estimates of acupuncture for irritable bowel syndrome (IBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched six English\u2010 and Chinese\u2010language databases. Eligible systematic reviews reported at least one direct pairwise meta\u2010analysis with recoverable study\u2010level inputs. Each eligible pooled estimate was recomputed. The primary outcome was result\u2010level numerical reproducibility. A prespecified standardized reanalysis was a key secondary analysis. Proportions used review\u2010clustered robust variance estimation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010three systematic reviews contributed 176 pooled estimates. Of these, 144 (81.8%, 95% confidence interval [CI] 71.4%\u201392.2%) reproduced exactly, 21 (11.9%, 95% CI 4.2%\u201319.7%) approximately, and 11 (6.3%, 95% CI 1.4%\u201311.1%) showed substantive numerical discrepancies. All 11 exceeded the 5% threshold for CI width, whereas 10 retained point estimates within 5% of the published value. No original\u2010method recomputation changed whether the 95% CI excluded the null value.\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      reproduced within one percentage point for 162 estimates (92.0%). The text and forest plot disagreed on the analytic model for 12 of 168 evaluable estimates (7.1%). Under the standardized framework, 26 of 174 estimable results (14.9%; 95% CI 7.5%\u201322.3%) changed from statistically significant to nonsignificant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Published pooled estimates were generally reproducible when study\u2010level inputs were recoverable, although uncertainty estimates were more sensitive than point estimates. Complete, internally consistent reporting and availability of data and code would facilitate independent verification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70188","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:46:40Z","timestamp":1789462000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reproducibility of Published Meta\u2010Analyses on Acupuncture for Irritable Bowel Syndrome"],"prefix":"10.1111","volume":"19","author":[{"given":"Yuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhen","family":"Zou","sequence":"additional","affiliation":[{"name":"West China School of Public Health Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Guo","sequence":"additional","affiliation":[{"name":"Innovation Institute for Integration of Medicine and Engineering West China Hospital Sichuan University  Chengdu China"},{"name":"West China Medical Publishers West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Deng","sequence":"additional","affiliation":[{"name":"Innovation Institute for Integration of Medicine and Engineering West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlin","family":"Long","sequence":"additional","affiliation":[{"name":"Innovation Institute for Integration of Medicine and Engineering West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"WHO Handbook for Guideline Development","author":"World Health Organization","year":"2014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.70120"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233107"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/25152459231202929"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2024.2782"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.4.430"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2024.111331"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001036"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005111.pub3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284818820438"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_2_7_14_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Deeks J. 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