{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:59:33Z","timestamp":1790330373844,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Living donors with hepatitis B virus (HBV) infection are increasingly accepted to alleviate organ shortages. However, after donor nephrectomy, the impact of HBV infection on long\u2010term kidney function remains unclear in individuals with a solitary functioning kidney.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective controlled cohort study to evaluate long\u2010term kidney and liver function, risk of end\u2010stage kidney disease (ESKD), cancer\u2010specific mortality, and all\u2010cause mortality between hepatitis B surface antigen\u2010positive (HBsAg+) donors and HBsAg\u2013 donors. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 128 HBsAg+ donors and 1145 HBsAg\u2013 donors. After a median follow\u2010up of 86.0 and 96.0 months, HBsAg+ donors demonstrated a greater increase in serum creatinine compared to HBsAg\u2013 donors (12.1 \u00b5mol\/L vs. 8.4 \u00b5mol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The rates of ESKD were 0.58 and 2.94 per 1000 person\u2010years, and the rates of estimated glomerular filtration rate (eGFR) &lt; 45\u00a0mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      were 3.65 and 9.99 per 1000 person\u2010years in the HBsAg\u2013 and HBsAg+ donors. Further, HBsAg+ donors had a higher risk of eGFR &lt; 45\u00a0mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      (HR: 2.21, 95% confidence interval [CI]: 1.06\u20134.63,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.035). The mortality was 1.4 and 6.85 per 1000 person\u2010years in HBsAg\u2013 and HBsAg+ donors, respectively. After full adjustment, HBsAg+ status was an independent risk factor of death (HR: 7.16, 95% CI: 1.71\u201329.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007). Sensitivity analyses after propensity score matching reported numerically higher incidence of ESKD and marginally higher incidence of eGFR &lt; 45\u00a0mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      . Stratified analyses revealed that hepatitis B e antigen\u2010positive status (\n                      <jats:italic>p &lt;<\/jats:italic>\n                      0.001) and hepatic damage (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005) may be associated with higher incidence of ESKD, while receiving anti\u2010HBV therapy may reduce the risk (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HBsAg+ individuals may have a higher absolute long\u2010term kidney failure risk and mortality after living donor nephrectomy. These findings might improve donation\u2010attributable risk estimates and add new information to the utilization and management of live donors with HBV infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70195","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:30:09Z","timestamp":1788769809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mortality and Kidney Failure Risk in HBsAg\u2010Positive Living Kidney Donors: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"19","author":[{"given":"Saifu","family":"Yin","sequence":"first","affiliation":[{"name":"West China School of Nursing West China Hospital, Sichuan University  Chengdu China"},{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Urology\/Institute of Urology West China Hospital, Sichuan University  Chengdu China"},{"name":"Kidney Transplantation Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"West China School of Nursing West China Hospital, Sichuan University  Chengdu China"},{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Urology\/Institute of Urology West China Hospital, Sichuan University  Chengdu China"},{"name":"Kidney Transplantation Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Practice West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Huang","sequence":"additional","affiliation":[{"name":"West China School of Nursing West China Hospital, Sichuan University  Chengdu China"},{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Urology\/Institute of Urology West China Hospital, Sichuan University  Chengdu China"},{"name":"Kidney Transplantation Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Systems Epidemiology West China School of Public Health and West China Fourth Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianding","family":"Wang","sequence":"additional","affiliation":[{"name":"West China School of Nursing West China Hospital, Sichuan University  Chengdu China"},{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Urology\/Institute of Urology West China Hospital, Sichuan University  Chengdu China"},{"name":"Kidney Transplantation Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lin","sequence":"additional","affiliation":[{"name":"West China School of Nursing West China Hospital, Sichuan University  Chengdu China"},{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Urology\/Institute of Urology West China Hospital, Sichuan University  Chengdu China"},{"name":"Kidney Transplantation Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01272.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002253"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","unstructured":"K. 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