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Despite ongoing advances in therapeutic techniques, the treatment of oral diseases still faces challenges. Cold atmospheric plasma (CAP)\u00a0is a non\u2010equilibrium plasma generated at atmospheric pressure. It is capable of producing various biologically reactive species, such as reactive oxygen species. In applications, CAP treatment demonstrates target specificity, excellent biocompatibility, and other advantages. It is currently attracting considerable attention in oral medicine. This review summarizes research advances in CAP across antimicrobial therapy, periodontitis, oral wound healing, mucosal\u2010associated diseases, and oral cancer. In addition, we introduce relevant research on the combined application of CAP treatment with other therapeutic strategies, including hydrogels and photodynamic therapy. 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