{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:44:58Z","timestamp":1791801898895,"version":"4.3.4"},"reference-count":90,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Evidence Based Medicine"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Stage at diagnosis is a key factor influencing survival in patients with esophageal cancer. This study aims to assess the distribution of esophageal cancer stage at diagnosis using registry data from multiple countries\/regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, CNKI, and WanFang Data were systematically searched, supplemented by grey literature from cancer registry reports. Population\u2010 or hospital\u2010based registry studies reporting stage distribution at diagnosis according to tumor\u2010node\u2010metastasis or Surveillance, Epidemiology, and End Results systems were included. Sex\u2010specific stage distributions, associations of the Human Development Index (HDI) and Socio\u2010Demographic Index (SDI) with distant metastasis, and temporal trends in stage distribution were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Stage data from 23 countries\/regions were included. Among the 22 countries\/regions in the primary analysis, the proportion of cases with distant metastasis varied substantially, with a median of 26.6% (interquartile range: 18.7%\u201335.9%), highest in Czechia (43.7%). Among the 11 countries\u00a0with sex\u2010stratified data, males had a higher proportion of distant metastasis than females in all but Norway. Weighted ecological analyses showed no statistically significant associations of HDI or SDI with the proportion of cases with distant metastasis (\n                      <jats:italic>p<\/jats:italic>\n                      &gt;\u00a00.05). Temporal trends showed that the proportion of distant metastasis remained generally stable in most countries\/regions, with the Republic of Korea below 20%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A substantial proportion of patients with esophageal cancer presented with distant metastasis at diagnosis, with marked regional and sex differences in stage distribution. Further research is needed to identify factors associated with stage variation and improve cancer registration and staging data quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jebm.70198","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:48:55Z","timestamp":1791798535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patterns of Esophageal Cancer Stage at Diagnosis: A Systematic Review of Registry\u2010Based Data"],"prefix":"10.1111","author":[{"given":"Lanwei","family":"Guo","sequence":"first","affiliation":[{"name":"Clinical Trials Center The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Clinical Trials Center The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"},{"name":"Department of Epidemiology School of Public Health Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou China"},{"name":"Department of Epidemiology School of Public Health Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Yuan","sequence":"additional","affiliation":[{"name":"Clinical Trials Center The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"},{"name":"Department of Epidemiology School of Public Health Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou China"},{"name":"Department of Epidemiology School of Public Health Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huamei","family":"Luan","sequence":"additional","affiliation":[{"name":"Clinical Trials Center The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"},{"name":"Department of Epidemiology School of Public Health Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cai","sequence":"additional","affiliation":[{"name":"Clinical Trials Center The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"},{"name":"Department of Epidemiology School of Public Health Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongda","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Prevention and Early Intervention National Infrastructures for Translational Medicine Institute of Clinical Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Prevention and Early Intervention National Infrastructures for Translational Medicine Institute of Clinical Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Clinical Trials Center The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Trials Center The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"International Agency for Research on Cancer \u201cCancer Today \u201d Lyon: International Agency for Research on Cancer 2026 https:\/\/gco.iarc.who.int\/today\/."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33326-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00548"},{"key":"e_1_2_8_5_1","article-title":"Survival Rates for Esophageal Cancer","author":"American Cancer Society","year":"2026","journal-title":"Atlanta: American Cancer Society"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2196\/45360"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01284"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00157-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34232"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-00289-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.4837"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.11.019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.18356\/9789211542639"},{"key":"e_1_2_8_15_1","unstructured":"Global Burden of Disease Collaborative Network \u201cGlobal Burden of Disease Study 2023 (GBD 2023) Socio\u2010Demographic Index (SDI) 1950\u20132023 \u201d Seattle: Institute for Health Metrics and Evaluation 2025 https:\/\/ghdx.healthdata.org\/record\/gbd\u20102023\u2010socio\u2010demographic\u2010index\u2010sdi."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000054"},{"key":"e_1_2_8_17_1","article-title":"Cancer Incidence in Five Continents, Vol. XII (IARC CancerBase no. 19)","author":"Bray F.","year":"2023","journal-title":"Lyon: International Agency for Research on Cancer"},{"key":"e_1_2_8_18_1","unstructured":"Korea Central Cancer Registry National Cancer Center Cancer Statistics in Korea 2022(Goyang: National Cancer Center 2024)."},{"key":"e_1_2_8_19_1","unstructured":"Belgian Cancer Registry Cancer Fact Sheet 2022: Oesophageal Cancer(Brussels: Belgian Cancer Registry 2025)."},{"key":"e_1_2_8_20_1","unstructured":"M. L.Zimmermann K.Innos K.Paapsi et\u00a0al. Cancer in Estonia: Incidence 2022 Survival 2018\u20132022 and HPV\u2010Related Cancers 1998\u20132022(Tallinn: National Institute for Health Development 2025)."},{"key":"e_1_2_8_21_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2021(Ljubljana: Institute of Oncology Ljubljana 2024)."},{"key":"e_1_2_8_22_1","unstructured":"Z.Fedorenko Y.Gorokh A.Ryzhov et\u00a0al. Cancer in Ukraine 2023\u20132024: Incidence Mortality Prevalence and Other Relevant Statistics(Kyiv: National Cancer Registry of Ukraine 2025)."},{"key":"e_1_2_8_23_1","unstructured":"Croatian Institute of Public Health Croatian National Cancer Registry Cancer Incidence in Croatia 2020(Zagreb: Croatian Institute of Public Health 2022)."},{"key":"e_1_2_8_24_1","unstructured":"Public Health Wales Welsh Cancer Intelligence and Surveillance Unit Cancer Incidence in Wales 2002\u20132022(Cardiff: Public Health Wales 2025)."},{"key":"e_1_2_8_25_1","unstructured":"Northern Ireland Cancer Registry Queen's University Belfast Cancer Incidence Survival Mortality and Prevalence Statistics: Northern Ireland 1993\u20132022(Belfast: Northern Ireland Cancer Registry 2025)."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8463195"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.04.001"},{"key":"e_1_2_8_28_1","unstructured":"Indian Council of Medical Research\u2014National Centre for Disease Informatics and Research Clinicopathological Profile of Cancers in India: A Report of the Hospital Based Cancer Registries(Bengaluru: ICMR\u2010NCDIR 2021)."},{"key":"e_1_2_8_29_1","unstructured":"Cancer Research UK \u201cCancer Stats \u201d London: Cancer Research UK Cancer Intelligence Team 2025 https:\/\/crukcancerintelligence.shinyapps.io\/EarlyDiagnosis\/."},{"key":"e_1_2_8_30_1","unstructured":"L.Du\u0161ek J.Mu\u017e\u00edk M.Kub\u00e1sek et\u00a0al. \u201cEpidemiology of Malignant Tumours in the Czech Republic \u201d Brno: Masaryk University 2005 https:\/\/www.svod.cz\/."},{"issue":"10","key":"e_1_2_8_31_1","first-page":"1215","article-title":"Impact of the COVID\u201019 Pandemic on the Diagnosis of Cancer in Japan: Analysis of Hospital\u2010Based Cancer Registries","volume":"52","author":"Okuyama A.","year":"2022","journal-title":"Japanese Journal of Clinical Oncology"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325266"},{"key":"e_1_2_8_33_1","unstructured":"Netherlands Comprehensive Cancer Organisation \u201cNKR Cijfers\u2014Incidentie per Jaar \u201d Utrecht: Netherlands Comprehensive Cancer Organisation 2025 https:\/\/nkr\u2010cijfers.iknl.nl\/viewer\/incidentie\u2010per\u2010jaar?language=en&viewerId=3de61d2a\u201076af\u201041fe\u2010a01f\u2010721e3d7bb50a."},{"key":"e_1_2_8_34_1","unstructured":"Centre for Disease Prevention and Control of Latvia \u201cONKO040: Number and Percentage Distribution of Malignant Neoplasms by Stage (Without Cases Registered From Death Certificates Only) \u201d Riga: Centre for Disease Prevention and Control of Latvia 2025 https:\/\/statistika.spkc.gov.lv:443\/pxweb\/en\/Health\/Health__Saslimstiba_Slimibu_Izplatiba__Onkologija\/ONKO040.px\/."},{"key":"e_1_2_8_35_1","unstructured":"Surveillance Research Program National Cancer Institute \u201cSEERExplorer: An Interactive Website for SEER Cancer Statistics \u201d Bethesda: National Cancer Institute 2025 https:\/\/seer.cancer.gov\/statistics\u2010network\/."},{"key":"e_1_2_8_36_1","unstructured":"Cancer Registry of Norway \u201cCancer in Norway \u201d Oslo: Cancer Registry of Norway https:\/\/sb.kreftregisteret.no\/."},{"key":"e_1_2_8_37_1","unstructured":"A.Brennan J.McDevitt H.Heidarian Miri et\u00a0al. The Initial Impact of COVID\u201019 on Cancer in Ireland: Incidence Stage at Diagnosis Mortality and 1\u2010Year Survival(Cork: National Cancer Registry Ireland 2025)."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.26090"},{"key":"e_1_2_8_39_1","volume-title":"Cancer in Germany 2017\/2018","year":"2022"},{"key":"e_1_2_8_40_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2010(Goyang: National Cancer Center 2012)."},{"key":"e_1_2_8_41_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2011(Goyang: National Cancer Center 2013)."},{"key":"e_1_2_8_42_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2012(Goyang: National Cancer Center 2014)."},{"key":"e_1_2_8_43_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2013(Goyang: National Cancer Center 2015)."},{"key":"e_1_2_8_44_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2014(Goyang: National Cancer Center 2016)."},{"key":"e_1_2_8_45_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2015(Goyang: National Cancer Center 2017)."},{"key":"e_1_2_8_46_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2016(Goyang: National Cancer Center 2018)."},{"key":"e_1_2_8_47_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2017(Goyang: National Cancer Center 2019)."},{"key":"e_1_2_8_48_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2018(Goyang: National Cancer Center 2021)."},{"key":"e_1_2_8_49_1","volume-title":"Annual Report of Cancer Statistics in Korea","author":"Korea Central Cancer Registry, National Cancer Center","year":"2019"},{"key":"e_1_2_8_50_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2020(Goyang: National Cancer Center 2022)."},{"key":"e_1_2_8_51_1","unstructured":"Korea Central Cancer Registry National Cancer Center Annual Report of Cancer Statistics in Korea 2021(Goyang: National Cancer Center 2023)."},{"key":"e_1_2_8_52_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2010(Ljubljana: Institute of Oncology Ljubljana 2013)."},{"key":"e_1_2_8_53_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2011(Ljubljana: Institute of Oncology Ljubljana 2014)."},{"key":"e_1_2_8_54_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2013(Ljubljana: Institute of Oncology Ljubljana 2016)."},{"key":"e_1_2_8_55_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2012(Ljubljana: Institute of Oncology Ljubljana 2015)."},{"key":"e_1_2_8_56_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2014(Ljubljana: Institute of Oncology Ljubljana 2017)."},{"key":"e_1_2_8_57_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2015(Ljubljana: Institute of Oncology Ljubljana 2018)."},{"key":"e_1_2_8_58_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2016(Ljubljana: Institute of Oncology Ljubljana 2019)."},{"key":"e_1_2_8_59_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2017(Ljubljana: Institute of Oncology Ljubljana 2020)."},{"key":"e_1_2_8_60_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2018(Ljubljana: Institute of Oncology Ljubljana 2021)."},{"key":"e_1_2_8_61_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2019(Ljubljana: Institute of Oncology Ljubljana 2022)."},{"key":"e_1_2_8_62_1","unstructured":"Institute of Oncology Ljubljana Epidemiology and Cancer Registry Slovenian Cancer Registry Cancer in Slovenia 2020(Ljubljana: Institute of Oncology Ljubljana 2023)."},{"key":"e_1_2_8_63_1","unstructured":"Croatian Institute of Public Health Croatian National Cancer Registry Cancer Incidence in Croatia 2012(Zagreb: Croatian Institute of Public Health 2014)."},{"key":"e_1_2_8_64_1","unstructured":"Croatian Institute of Public Health Croatian National Cancer Registry Cancer Incidence in Croatia 2013(Zagreb: Croatian Institute of Public Health 2015)."},{"key":"e_1_2_8_65_1","unstructured":"Croatian Institute of Public Health Croatian National Cancer Registry Cancer Incidence in Croatia 2014(Zagreb: Croatian Institute of Public Health 2016)."},{"key":"e_1_2_8_66_1","unstructured":"Croatian Institute of Public Health Croatian National Cancer Registry Cancer Incidence in Croatia 2015(Zagreb: Croatian Institute of Public Health 2018)."},{"key":"e_1_2_8_67_1","unstructured":"Croatian Institute of Public Health Croatian National Cancer Registry Cancer Incidence in Croatia 2016(Zagreb: Croatian Institute of Public Health 2019)."},{"key":"e_1_2_8_68_1","unstructured":"Croatian Institute of Public Health Croatian National Cancer Registry Cancer Incidence in Croatia 2017(Zagreb: Croatian Institute of Public Health 2020)."},{"key":"e_1_2_8_69_1","unstructured":"Croatian Institute of Public Health Croatian National Cancer Registry Cancer Incidence in Croatia 2018(Zagreb: Croatian Institute of Public Health 2020)."},{"key":"e_1_2_8_70_1","unstructured":"Croatian Institute of Public Health Croatian National Cancer Registry Cancer Incidence in Croatia 2019(Zagreb: Croatian Institute of Public Health 2021)."},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-021-06113-x"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33208"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315520"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.01.029"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154337"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/gidisord7030049"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001680"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305372"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12913"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-11583-x"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101367"},{"key":"e_1_2_8_82_1","unstructured":"National Health Insurance Service \u201cHealth Checkup Benefits \u201d Wonju: NHIS 2025 https:\/\/www.nhis.or.kr\/english\/wbheaa02600m01.do."},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.07.015"},{"key":"e_1_2_8_84_1","unstructured":"E.MedhurstandL.Habashi Lung Cancer Care in Croatia: How Effective Policy Can Transform Outcomes(London: The Health Policy Partnership 2025)."},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.0618"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101469"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2024.0224"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.09.001"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2025.116063"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16990"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goab010"}],"container-title":["Journal of Evidence-Based Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.70198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jebm.70198","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jebm.70198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:49:06Z","timestamp":1791798546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jebm.70198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":90,"alternative-id":["10.1111\/jebm.70198"],"URL":"https:\/\/doi.org\/10.1111\/jebm.70198","archive":["Portico"],"relation":{},"ISSN":["1756-5383","1756-5391"],"issn-type":[{"value":"1756-5383","type":"print"},{"value":"1756-5391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"2026-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70198"}}