{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:27:16Z","timestamp":1770722836078,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University in Prague","doi-asserted-by":"crossref","award":["SVV 260 066"],"award-info":[{"award-number":["SVV 260 066"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>Rationale, aims and objectives<\/jats:title>In rheumatic disorders, one of the treatment objectives is to improve the patient's quality of life (QoL<\/jats:styled-content>). Similar to other chronic conditions, drug compliance is poor, but necessary for successful treatment. The relationship between drug compliance and QoL<\/jats:styled-content> has never been tested. The aim of this study was to elucidate the relationship between drug compliance and QoL<\/jats:styled-content> in patients with different rheumatic disorders.<\/jats:p><\/jats:sec>Method<\/jats:title>A cross\u2010sectional study was conducted and patients \u226518 years of age with rheumatoid arthritis (RA<\/jats:styled-content>), spondyloarthritis (SA<\/jats:styled-content>), juvenile idiopathic arthritis (JIA<\/jats:styled-content>) and systemic scleroderma (SSc<\/jats:styled-content>) were recruited. Data were collected by questionnaires including the S<\/jats:styled-content>hort F<\/jats:styled-content>orm 36 version 2, C<\/jats:styled-content>ompliance Q<\/jats:styled-content>uestionnaire R<\/jats:styled-content>heumatology (CQR<\/jats:styled-content>), H<\/jats:styled-content>ealth A<\/jats:styled-content>ssessment Q<\/jats:styled-content>uestionnaire and by a general questionnaire that focused on demographic characteristics.<\/jats:p><\/jats:sec>Results<\/jats:title>The questionnaires were completed by 289 patients. Of the respondents, 61.6% (178) were treated for RA<\/jats:styled-content>, 16.3% (47) for SA<\/jats:styled-content>, 14.2% (41) for SSc<\/jats:styled-content> and 8% (23) for JIA<\/jats:styled-content>. The median of CQR<\/jats:styled-content> score ranged from 66.7 (JIA<\/jats:styled-content>) to 82.5 (RA<\/jats:styled-content>), with 51.6% of patients reaching a score <80. QoL<\/jats:styled-content> was decreased mainly in the physical component, with the lowest rate for patients with SSc<\/jats:styled-content>. Higher compliance was observed in patients with decreased QoL<\/jats:styled-content> (physical component), nevertheless, statistical significance of the relationship was reached only in JIA<\/jats:styled-content> and SA<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Doctors caring for rheumatic patients should focus their efforts on strengthening drug compliance in patients with higher QoL<\/jats:styled-content> where it seems that lower compliance is more likely.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jep.12399","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T10:25:08Z","timestamp":1434536708000},"page":"919-924","source":"Crossref","is-referenced-by-count":17,"title":["Quality of life and drug compliance: their interrelationship in rheumatic patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Lucie","family":"Hromadkova","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Hospital Na Homolce Prague Czech Republic"},{"name":"Hospital Pharmacy Masaryk Hospital Usti nad Labem Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Soukup","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine \u2013 Gastroenterology University Hospital and Faculty of Medicine Charles University in Prague Hradec Kralove Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Vlcek","sequence":"additional","affiliation":[{"name":"Department of Social and Clinical Pharmacy Faculty of Pharmacy Charles University in Prague Hradec Kralove Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-25"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-0970-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.01.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000114908.90348.f9"},{"issue":"10","key":"e_1_2_7_6_1","first-page":"596","article-title":"Patient adherence to pharmacotherapy: the importance of effective communication","volume":"30","author":"DiMatteo M. 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